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Literature summary extracted from

  • Juvale, K.; Shaik, A.; Kirubakaran, S.
    Inhibitors of inosine 5'-monophosphate dehydrogenase as emerging new generation antimicrobial agents (2019), MedChemComm, 10, 1290-1301 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 (1H-naphtho[2,3-d]imidazol-2-yl)methyl 4-aminobenzoate
-
 Cryptosporidium parvum
1.1.1.205 (2R)-2-[(naphthalen-1-yl)oxy]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide Q21 Bacillus anthracis
1.1.1.205 (2R)-2-[(naphthalen-1-yl)oxy]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide Q21 Cryptosporidium parvum
1.1.1.205 (2R)-2-[(naphthalen-1-yl)oxy]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide Q21 Listeria monocytogenes
1.1.1.205 (2S)-2-(2,3-dichloroanilino)-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide Q67 Mycobacterium tuberculosis
1.1.1.205 (2S)-N-(4-iodophenyl)-2-(4-methoxyphenoxy)propanamide 7759844 Mycolicibacterium thermoresistibile
1.1.1.205 (2S)-N-[5-(4-bromophenyl)-1H-imidazol-2-yl]-2-[4-(1-methyl-1H-imidazol-4-yl)phenoxy]propanamide AT080 Mycolicibacterium thermoresistibile
1.1.1.205 (5S)-7-amino-5-(4-chlorophenyl)-2,4-dioxo-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carbonitrile F2K Pseudomonas aeruginosa
1.1.1.205 2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(6,7,8,9-tetrahydrodibenzo[b,d]furan-2-yl)acetamide D67 Bacillus anthracis
1.1.1.205 2-chloro-5-[[(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)carbamoyl]amino]benzamide P32 Bacillus anthracis
1.1.1.205 2-chloro-N,N-dimethyl-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl[carbamoyl)amino]benzamide P41 Mycobacterium tuberculosis
1.1.1.205 2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
-
 Cryptosporidium parvum
1.1.1.205 3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate
-
 Cryptosporidium parvum
1.1.1.205 3-(2-[[(4-chlorophenyl)carbamoyl]amino]propan-2-yl)-N-hydroxybenzene-1-carboximidamide P200 Bacillus anthracis
1.1.1.205 3-(2-[[(4-chlorophenyl)carbamoyl]amino]propan-2-yl)-N-hydroxybenzene-1-carboximidamide P200 Campylobacter jejuni
1.1.1.205 3-(2-[[(4-chlorophenyl)carbamoyl]amino]propan-2-yl)-N-hydroxybenzene-1-carboximidamide P200 Clostridium perfringens
1.1.1.205 4-(4-bromophenyl)-1H-imidazole NMR744 Mycolicibacterium thermoresistibile
1.1.1.205 4-[(1R)-1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]ethoxy]quinolin-2(1H)-one A110 Bacillus anthracis
1.1.1.205 4-[(1R)-1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]ethoxy]quinolin-2(1H)-one A110 Clostridium perfringens
1.1.1.205 5'-O-([1-[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]-1H-1,2,3-triazol-4-yl[methyl)adenosine MAD1, uncompetitive inhibitor Mycobacterium tuberculosis
1.1.1.205 5-([[2-([1,1'-biphenyl]-3-yl)propan-2-yl]carbamoyl]amino)-2-chlorobenzamide
-
 Cryptosporidium parvum
1.1.1.205 cyclohexyl[4-(isoquinoline-5-sulfonyl)piperazin-1-yl]methanone VCC234718 Mycolicibacterium thermoresistibile
1.1.1.205 methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate
-
 Cryptosporidium parvum
1.1.1.205 Mycophenolic acid
-
 Vibrio cholerae
1.1.1.205 N-(2-{3-[(1E)-N-(2-aminoethoxy)ethanimidoyl]phenyl}propan-2-yl)-N'-(4-chloro-3-nitrophenyl)urea P131 Cryptosporidium parvum
1.1.1.205 N-(2H-indazol-6-yl)-3,5-dimethyl-1H-pyrazole-4-sulfonamide TBK6 Mycobacterium tuberculosis
1.1.1.205 N-(2H-indazol-6-yl)-3,5-dimethyl-1H-pyrazole-4-sulfonamide TBK6 Mycolicibacterium thermoresistibile
1.1.1.205 N-(4-bromophenyl)-2-[2-(1,3-thiazol-2-yl)-1H-benzimidazol-1-yl]acetamide
-
 Cryptosporidium parvum
1.1.1.205 N-(4-bromophenyl)-N'-(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)urea P68 Bacillus anthracis
1.1.1.205 N-(4-bromophenyl)-N'-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]urea P12 Campylobacter jejuni
1.1.1.205 N-(4-chloro-3-methoxyphenyl)-2-(4-oxo[1]benzopyrano[4,3-c]pyrazol-1(4H)-yl)acetamide
-
 Cryptosporidium parvum
1.1.1.205 N-(4-chlorophenyl)-2-phenoxypropanamide
-
 Cryptosporidium parvum
1.1.1.205 N-(4-fluorophenyl)-4-[(2H-indazol-6-yl)sulfamoyl]-3,5-dimethyl-1H-pyrrole-2-carboxamide
-
 Mycolicibacterium thermoresistibile
1.1.1.205 N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
-
 Cryptosporidium parvum
1.1.1.205 N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide
-
 Cryptosporidium parvum
1.1.1.205 N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
-
 Cryptosporidium parvum
1.1.1.205 N-(naphthalen-2-yl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
-
 Cryptosporidium parvum
1.1.1.205 N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide C91 Bacillus anthracis
1.1.1.205 N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide C91 Campylobacter jejuni
1.1.1.205 N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide C91 Clostridium perfringens
1.1.1.205 N-naphthalen-2-yl-N'-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]urea
-
 Cryptosporidium parvum
1.1.1.205 N-[(1R)-1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]ethyl[-N'-phenylurea G36 Mycobacterium tuberculosis
1.1.1.205 N-[2-chloro-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]carbamoyl)amino]phenyl]-beta-D-xylofuranosylamine P176; P221 Bacillus anthracis
1.1.1.205 N-[2-chloro-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]carbamoyl)amino]phenyl]-beta-D-xylofuranosylamine P176; P221 Clostridium perfringens
1.1.1.205 N-[2-chloro-5-[([2-[3-(propan-2-yl)phenyl]propan-2-yl]carbamoyl)amino]phenyl]-?-D-ribofuranosylamine P176 Campylobacter jejuni
1.1.1.205 N-[4-chloro-3-(alpha-D-ribofuranosyloxy)phenyl]-N'-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]urea P178 Bacillus anthracis
1.1.1.205 N-[4-chloro-3-(alpha-D-ribofuranosyloxy)phenyl]-N'-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]urea P178 Clostridium perfringens
1.1.1.205 N-[4-chloro-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl]-N'-(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)urea P182 Bacillus anthracis
1.1.1.205 N-[4-chloro-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl]-N'-(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)urea P182 Campylobacter jejuni
1.1.1.205 N-[4-chloro-3-[4-(trifluoromethyl)-1,3-thiazol-2-yl]phenyl]-N'-(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)urea P182 Clostridium perfringens
1.1.1.205 oxanosine monophosphate
-
 Bacillus anthracis
1.1.1.205 [2-chloro-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]carbamoyl)amino]phenoxy]acetic acid P225 Campylobacter jejuni
1.1.1.205 [2-chloro-5-[([2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]carbamoyl)amino]phenoxy]acetic acid P225 Clostridium perfringens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.205 IMP + NAD+ + H2O Cryptosporidium parvum
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Bacillus anthracis
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Pseudomonas aeruginosa
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Mycobacterium tuberculosis
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Campylobacter jejuni
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Mycolicibacterium thermoresistibile
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Clostridium perfringens
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Vibrio cholerae
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Listeria monocytogenes
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Bacillus anthracis Ames
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Mycolicibacterium thermoresistibile ATCC 19527
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Listeria monocytogenes ATCC BAA-679
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Mycobacterium tuberculosis H37Rv
-
 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O Vibrio cholerae ATCC 39315
-
 XMP + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Bacillus anthracis
-
-
-
1.1.1.205 Bacillus anthracis A0A6L8P2U9
-
-
1.1.1.205 Bacillus anthracis Ames
-
-
-
1.1.1.205 Campylobacter jejuni A0A2R4D3F6
-
-
1.1.1.205 Clostridium perfringens A0A127ELD1
-
-
1.1.1.205 Cryptosporidium parvum
-
-
-
1.1.1.205 Listeria monocytogenes Q926Y9
-
-
1.1.1.205 Listeria monocytogenes ATCC BAA-679 Q926Y9
-
-
1.1.1.205 Mycobacterium tuberculosis P9WKI7
-
-
1.1.1.205 Mycobacterium tuberculosis H37Rv P9WKI7
-
-
1.1.1.205 Mycolicibacterium thermoresistibile G7CNL4
-
-
1.1.1.205 Mycolicibacterium thermoresistibile ATCC 19527 G7CNL4
-
-
1.1.1.205 Pseudomonas aeruginosa Q9HXM5
-
-
1.1.1.205 Vibrio cholerae Q9KTW3
-
-
1.1.1.205 Vibrio cholerae ATCC 39315 Q9KTW3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.205 IMP + NAD+ + H2O
-
 Cryptosporidium parvum XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Bacillus anthracis XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Pseudomonas aeruginosa XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Mycobacterium tuberculosis XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Campylobacter jejuni XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Mycolicibacterium thermoresistibile XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Clostridium perfringens XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Vibrio cholerae XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Listeria monocytogenes XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Bacillus anthracis Ames XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Mycolicibacterium thermoresistibile ATCC 19527 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Listeria monocytogenes ATCC BAA-679 XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Mycobacterium tuberculosis H37Rv XMP + NADH + H+
-
 ?
1.1.1.205 IMP + NAD+ + H2O
-
 Vibrio cholerae ATCC 39315 XMP + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.205 guaB2
-
 Mycobacterium tuberculosis
1.1.1.205 IMPDH
-
 Cryptosporidium parvum
1.1.1.205 IMPDH
-
 Bacillus anthracis
1.1.1.205 IMPDH
-
 Pseudomonas aeruginosa
1.1.1.205 IMPDH
-
 Mycobacterium tuberculosis
1.1.1.205 IMPDH
-
 Campylobacter jejuni
1.1.1.205 IMPDH
-
 Mycolicibacterium thermoresistibile
1.1.1.205 IMPDH
-
 Clostridium perfringens
1.1.1.205 IMPDH
-
 Vibrio cholerae
1.1.1.205 IMPDH
-
 Listeria monocytogenes
1.1.1.205 inosine 5'-monophosphate dehydrogenase
-
 Cryptosporidium parvum
1.1.1.205 inosine 5'-monophosphate dehydrogenase
-
 Bacillus anthracis
1.1.1.205 inosine 5'-monophosphate dehydrogenase
-
 Pseudomonas aeruginosa
1.1.1.205 inosine 5'-monophosphate dehydrogenase
-
 Mycobacterium tuberculosis
1.1.1.205 inosine 5'-monophosphate dehydrogenase
-
 Campylobacter jejuni
1.1.1.205 inosine 5'-monophosphate dehydrogenase
-
 Mycolicibacterium thermoresistibile
1.1.1.205 inosine 5'-monophosphate dehydrogenase
-
 Clostridium perfringens
1.1.1.205 inosine 5'-monophosphate dehydrogenase
-
 Vibrio cholerae
1.1.1.205 inosine 5'-monophosphate dehydrogenase
-
 Listeria monocytogenes

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.205 NAD+
-
 Cryptosporidium parvum
1.1.1.205 NAD+
-
 Bacillus anthracis
1.1.1.205 NAD+
-
 Pseudomonas aeruginosa
1.1.1.205 NAD+
-
 Mycobacterium tuberculosis
1.1.1.205 NAD+
-
 Campylobacter jejuni
1.1.1.205 NAD+
-
 Mycolicibacterium thermoresistibile
1.1.1.205 NAD+
-
 Clostridium perfringens
1.1.1.205 NAD+
-
 Vibrio cholerae
1.1.1.205 NAD+
-
 Listeria monocytogenes

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.205 0.0000021
-
 pH and temperature not specified in the publication Cryptosporidium parvum N-naphthalen-2-yl-N'-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]urea
1.1.1.205 0.000004
-
 pH and temperature not specified in the publication Cryptosporidium parvum 5-([[2-([1,1'-biphenyl]-3-yl)propan-2-yl]carbamoyl]amino)-2-chlorobenzamide
1.1.1.205 0.0001
-
 pH and temperature not specified in the publication Cryptosporidium parvum (1H-naphtho[2,3-d]imidazol-2-yl)methyl 4-aminobenzoate
1.1.1.205 0.0009
-
 pH and temperature not specified in the publication Cryptosporidium parvum 3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate
1.1.1.205 0.0012
-
 pH and temperature not specified in the publication Cryptosporidium parvum N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
1.1.1.205 0.0014
-
 pH and temperature not specified in the publication Cryptosporidium parvum 2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
1.1.1.205 0.0016
-
 pH and temperature not specified in the publication Cryptosporidium parvum methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate
1.1.1.205 0.0016
-
 pH and temperature not specified in the publication Cryptosporidium parvum N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide
1.1.1.205 0.0033
-
 pH and temperature not specified in the publication Cryptosporidium parvum N-(4-chlorophenyl)-2-phenoxypropanamide
1.1.1.205 0.0054
-
 pH and temperature not specified in the publication Cryptosporidium parvum N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide