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Literature summary extracted from

  • Ericson, M.E.; Subramanian, C.; Frank, M.W.; Rock, C.O.
    Role of fatty acid kinase in cellular lipid homeostasis and SaeRS-dependent virulence factor expression in Staphylococcus aureus (2017), mBio, 8, e00988-17 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.2.18 expressed in Escherichia coli BL21 cells Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.7.2.18 Staphylococcus aureus
-
-
-
2.7.2.18 Staphylococcus aureus USA300
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.2.18 Ni-NTA column chromatography Staphylococcus aureus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.2.18 ATP + oleate
-
 Staphylococcus aureus ADP + oleyl phosphate
-
 ?
2.7.2.18 ATP + oleate
-
 Staphylococcus aureus USA300 ADP + oleyl phosphate
-
 ?
2.7.2.18 additional information the enzyme does not phosphorylate SaeS or SaeR Staphylococcus aureus ?
-
-
2.7.2.18 additional information the enzyme does not phosphorylate SaeS or SaeR Staphylococcus aureus USA300 ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.2.18 FA kinase
-
 Staphylococcus aureus
2.7.2.18 fakA kinase domain Staphylococcus aureus
2.7.2.18 FakAB
-
 Staphylococcus aureus

General Information

EC Number General Information Comment Organism
2.7.2.18 metabolism the enzyme activates SaeRS-dependent virulence factor production by lowering inhibitory fatty acid levels. Thus, the enzyme plays a role in cellular lipid homeostasis by activating fatty acid for incorporation into phospholipid, and it indirectly regulates SaeRS signaling by maintaining a low intracellular fatty acid pool Staphylococcus aureus