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Literature summary extracted from

  • Hong, W.; Guo, F.; Yang, M.; Xu, D.; Zhuang, Z.; Niu, B.; Bai, Q.; Li, X.
    Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent (2019), Lipids Health Dis., 18, 203 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.2 gene Sult2b1, recombinant overexpression of Ad-CMV-SULT2B1b via adenovirus vector in human wild-type and SULT2B1b-knockout GES-1 cells, quantitative RT-PCR enzyme expression analysis Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.8.2.2 additional information SULT2B1b overexpression promotes gastric epithelial cell proliferation via the PI3K/AKT signaling pathway Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.2 3'-phosphoadenylyl sulfate + (S)-cholest-5-ene-3beta,24S-diol Mus musculus
-
 adenosine 3',5'-bisphosphate + (S)-cholest-5-ene-3beta,24S-diol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 24(R/S),25-epoxycholesterol Mus musculus
-
 adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 4beta-hydroxycholesterol Mus musculus
-
 adenosine 3',5'-bisphosphate + 4beta-hydroxycholesterol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 7-oxocholesterol Mus musculus
-
 adenosine 3',5'-bisphosphate + 7-oxocholesterol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 7alpha-hydroxycholesterol Mus musculus
-
 adenosine 3',5'-bisphosphate + 7alpha-hydroxycholesterol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 7beta-hydroxycholesterol Mus musculus
-
 adenosine 3',5'-bisphosphate + 7beta-hydroxycholesterol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + cholest-5-ene-3beta,25-diol Mus musculus
-
 adenosine 3',5'-bisphosphate + cholest-5-ene-3beta,25-diol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + cholest-5-ene-3beta,27-diol Mus musculus
-
 adenosine 3',5'-bisphosphate + cholest-5-ene-3beta,27-diol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + cholesterol Mus musculus
-
 adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.2 Mus musculus O35400
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.2 gastric epithelium abundant SULT2B1 expression in normal gastric epithelium Mus musculus
-
2.8.2.2 primary cell
-
 Mus musculus
-
2.8.2.2 stomach
-
 Mus musculus
-
2.8.2.2 stomach epithelium
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.2 3'-phosphoadenylyl sulfate + (S)-cholest-5-ene-3beta,24S-diol
-
 Mus musculus adenosine 3',5'-bisphosphate + (S)-cholest-5-ene-3beta,24S-diol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 24(R/S),25-epoxycholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + ?
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 4beta-hydroxycholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + 4beta-hydroxycholesterol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 7-oxocholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + 7-oxocholesterol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 7alpha-hydroxycholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + 7alpha-hydroxycholesterol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + 7beta-hydroxycholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + 7beta-hydroxycholesterol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + cholest-5-ene-3beta,25-diol
-
 Mus musculus adenosine 3',5'-bisphosphate + cholest-5-ene-3beta,25-diol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + cholest-5-ene-3beta,27-diol
-
 Mus musculus adenosine 3',5'-bisphosphate + cholest-5-ene-3beta,27-diol 3-sulfate
-
 ?
2.8.2.2 3'-phosphoadenylyl sulfate + cholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + cholesterol 3-sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.2 hydroxysteroid sulfotransferase 2B1
-
 Mus musculus
2.8.2.2 More cf. EC 2.8.2.15 Mus musculus
2.8.2.2 SULT2B1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.8.2.2 malfunction gastric tumor incidence is higher in the SULT2B1-/- mice than in the wild-type mice. In gastric epithelial cells, adenovirus-mediated SULT2B1b overexpression reduces the levels of oxysterols, such as 24(R/S),25-epoxycholesterol (24(R/S),25-EC) and 27-hydroxycholesterol. This condition also increases PI3K/AKT signaling to promote gastric epithelial cell proliferation, epithelization, and epithelial development. SULT2B1 deletion or SULT2B1 knockdown suppresses PI3K/AKT signaling, epithelial cell epithelization, and wound healing and induced gastric epithelial cell malignant transition upon 3-MCA induction. SULT2B1 deletion inhibited PI3K/AKT signaling in response to growth factors, but SULT2B1 overexpression promotes this pathway Mus musculus
2.8.2.2 metabolism SULT2B1b overexpression reduces the levels of oxysterols, such as 24(R/S),25-epoxycholesterol (24(R/S),25-EC) and 27-hydroxycholesterol. This condition also increases PI3K/AKT signaling to promote gastric epithelial cell proliferation, epithelization, and epithelial development. The PI3K/AKT signaling pathway plays essential roles in normal cellular functions, such as protein synthesis, growth control, and nutrition/energy balance. PI3K/AKT activation by growth factors can stimulate protein synthesis and cell growth Mus musculus
2.8.2.2 physiological function hydroxysteroid sulfotransferase 2B1 (SULT2B1) affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent. The abundant SULT2B1 expression in normal gastric epithelium might maintain epithelial function via the PI3K/AKT signaling pathway and suppress gastric carcinogenesis induced by a carcinogenic agent. Enzyme SULT2B1 is involved in epithelial development Mus musculus