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Literature summary extracted from

  • Urbanek, K.; Sutherland, D.M.; Orchard, R.C.; Wilen, C.B.; Knowlton, J.J.; Aravamudhan, P.; Taylor, G.M.; Virgin, H.W.; Dermody, T.S.
    Cytidine monophosphate N-acetylneuraminic acid synthetase and solute carrier family 35 member A1 are required for reovirus binding and infection (2020), J. Virol., 95, e01571-20 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.43 CTP + N-acetylneuraminate Mus musculus
-
 diphosphate + CMP-N-acetylneuraminate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.43 Mus musculus Q99KK2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.43 BV-2 cell
-
 Mus musculus
-
2.7.7.43 microglia
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.43 CTP + N-acetylneuraminate
-
 Mus musculus diphosphate + CMP-N-acetylneuraminate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.43 CMAS
-
 Mus musculus
2.7.7.43 CMP-SA synthase
-
 Mus musculus
2.7.7.43 cytidine monophosphate N-acetylneuraminic acid synthetase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.7.43 malfunction cells lacking functional enzyme display increased viability during reovirus infection Mus musculus
2.7.7.43 physiological function the enzyme gene is required for serotype 3 reovirus binding and infection of microglial cells Mus musculus