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Literature summary extracted from

  • Beck, K.R.; Kanagaratnam, S.; Kratschmar, D.V.; Birk, J.; Yamaguchi, H.; Sailer, A.W.; Seuwen, K.; Odermatt, A.
    Enzymatic interconversion of the oxysterols 7beta,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11beta-hydroxysteroid dehydrogenase type 1 and 2 (2019), J. Steroid Biochem. Mol. Biol., 190, 19-28 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 7-keto,25-hydroxycholesterol inhibits the oxoreduction of cortisone to cortisol by the recombinant isoform 11beta-HSD1 Homo sapiens
1.1.1.146 7-keto,25-hydroxycholesterol
-
 Mus musculus
1.1.1.146 7alpha,25-Dihydroxycholesterol
-
 Homo sapiens
1.1.1.146 7beta,25-dihydroxycholesterol
-
 Homo sapiens
1.1.1.146 7beta,25-dihydroxycholesterol
-
 Mus musculus
1.1.1.146 glycyrrhetinic acid
-
 Homo sapiens
1.1.1.146 additional information not inhibited by 7alpha,25-dihydroxycholesterol Homo sapiens
1.1.1.146 additional information isoform 11beta-HSD2 is not inhibited by 7alpha,25-dihydroxycholesterol Mus musculus
1.1.1.146 T0504
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.146 0.000029
-
 7beta,25-dihydroxycholesterol recombinant isoform 11beta-HSD1, at pH 7.4 and 37°C Homo sapiens
1.1.1.146 0.000556
-
 7beta,25-dihydroxycholesterol recombinant isoform 11beta-HSD2, at pH 7.4 and 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.146 microsome
-
 Homo sapiens
-
-
1.1.1.146 microsome
-
 Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.146 Mg2+ 1 mM used in assay conditions Homo sapiens
1.1.1.146 Mg2+ 1 mM used in assay conditions Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisol + NAD+ Homo sapiens
-
 cortisone + NADH + H+
-
 ?
1.1.1.146 cortisol + NAD+ Mus musculus
-
 cortisone + NADH + H+
-
 ?
1.1.1.146 cortisone + NADPH + H+ Homo sapiens
-
 cortisol + NADP+
-
 ?
1.1.1.146 cortisone + NADPH + H+ Mus musculus
-
 cortisol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens P28845
-
-
1.1.1.146 Homo sapiens P80365
-
-
1.1.1.146 Mus musculus P50172
-
-
1.1.1.146 Mus musculus P51661
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 HEK-293 cell
-
 Homo sapiens
-
1.1.1.146 kidney
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 7-keto,25-hydroxycholesterol + NADPH + H+
-
 Homo sapiens 7beta,25-dihydroxycholesterol + NADP+
-
 ?
1.1.1.146 7-keto,25-hydroxycholesterol + NADPH + H+
-
 Mus musculus 7beta,25-dihydroxycholesterol + NADP+
-
 ?
1.1.1.146 7-ketocholesterol + NADPH + H+
-
 Homo sapiens 7beta-hydroxycholesterol + NADP+
-
 ?
1.1.1.146 7-ketocholesterol + NADPH + H+
-
 Mus musculus 7beta-hydroxycholesterol + NADP+
-
 ?
1.1.1.146 7beta,25-dihydroxycholesterol + NAD+
-
 Homo sapiens 7-keto,25-hydroxycholesterol + NADH + H+
-
 ?
1.1.1.146 7beta,25-dihydroxycholesterol + NAD+
-
 Mus musculus 7-keto,25-hydroxycholesterol + NADH + H+
-
 ?
1.1.1.146 corticosterone + NAD+
-
 Mus musculus 11-dehydrocorticosterone + NADH + H+
-
 ?
1.1.1.146 cortisol + NAD+
-
 Homo sapiens cortisone + NADH + H+
-
 ?
1.1.1.146 cortisol + NAD+
-
 Mus musculus cortisone + NADH + H+
-
 ?
1.1.1.146 cortisone + NADPH + H+
-
 Homo sapiens cortisol + NADP+
-
 ?
1.1.1.146 cortisone + NADPH + H+
-
 Mus musculus cortisol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD1
-
 Homo sapiens
1.1.1.146 11beta-HSD1
-
 Mus musculus
1.1.1.146 11beta-HSD2
-
 Homo sapiens
1.1.1.146 11beta-HSD2
-
 Mus musculus
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Mus musculus
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 2
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 2
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.146 0.000049
-
 recombinant isoform 11beta-HSD2, at pH 7.4 and 37°C Homo sapiens 7-keto,25-hydroxycholesterol
1.1.1.146 0.000053
-
 recombinant isoform 11beta-HSD1, at pH 7.4 and 37°C Mus musculus 7-keto,25-hydroxycholesterol
1.1.1.146 0.000091
-
 recombinant isoform 11beta-HSD2, at pH 7.4 and 37°C Homo sapiens 7beta,25-dihydroxycholesterol
1.1.1.146 0.000119
-
 recombinant isoform 11beta-HSD1, at pH 7.4 and 37°C Mus musculus 7beta,25-dihydroxycholesterol
1.1.1.146 0.000405
-
 recombinant isoform 11beta-HSD1, at pH 7.4 and 37°C Homo sapiens 7-keto,25-hydroxycholesterol
1.1.1.146 0.002
-
 IC50 of more than 0.002 mM, recombinant isoform 11beta-HSD2, at pH 7.4 and 37°C Mus musculus 7-keto,25-hydroxycholesterol
1.1.1.146 0.003
-
 IC50 of more than 0.003 mM, recombinant isoform 11beta-HSD1, at pH 7.4 and 37°C Homo sapiens 7beta,25-dihydroxycholesterol
1.1.1.146 0.003
-
 recombinant isoform 11beta-HSD2, at pH 7.4 and 37°C Mus musculus 7beta,25-dihydroxycholesterol