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Literature summary extracted from

  • Wu, Y.; Chen, P.; Sun, L.; Yuan, S.; Cheng, Z.; Lu, L.; Du, H.; Zhan, M.
    Sepiapterin reductase Characteristics and role in diseases (2020), J. Cell. Mol. Med., 24, 9495-9506 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.1.1.153 medicine the enzyme can regulate chronic pain and is a target for the development of analgesics Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.153 6-Carboxypterin
-
 Homo sapiens
1.1.1.153 acetic acid
-
 Homo sapiens
1.1.1.153 dicoumarol
-
 Homo sapiens
1.1.1.153 Ethacrynic acid
-
 Homo sapiens
1.1.1.153 indomethacin
-
 Homo sapiens
1.1.1.153 Isosepiapterin
-
 Homo sapiens
1.1.1.153 mesalamine
-
 Homo sapiens
1.1.1.153 N-acetylserotonin
-
 Homo sapiens
1.1.1.153 N-acetylsulfapyridine
-
 Homo sapiens
1.1.1.153 n-butyric acid
-
 Homo sapiens
1.1.1.153 propionic acid
-
 Homo sapiens
1.1.1.153 QM385
-
 Homo sapiens
1.1.1.153 rutin
-
 Homo sapiens
1.1.1.153 SPRi3
-
 Homo sapiens
1.1.1.153 sulfamethoxazole
-
 Homo sapiens
1.1.1.153 sulfapyridine
-
 Homo sapiens
1.1.1.153 sulfasalazine
-
 Homo sapiens
1.1.1.153 sulfathiazole
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.153 1'-oxo-2'-hydroxypropyl-tetrahydropterin + NADPH + H+ Homo sapiens
-
 tetrahydrobiopterin + NADP+
-
 ?
1.1.1.153 sepiapterin + NADPH + H+ Homo sapiens
-
 7,8-dihydrobiopterin + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.153 Homo sapiens P35270
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.153 BE(2)M17 cell
-
 Homo sapiens
-
1.1.1.153 brain
-
 Homo sapiens
-
1.1.1.153 cerebral cortex
-
 Homo sapiens
-
1.1.1.153 colon
-
 Homo sapiens
-
1.1.1.153 colorectal cancer cell
-
 Homo sapiens
-
1.1.1.153 Hep-G2 cell
-
 Homo sapiens
-
1.1.1.153 kidney
-
 Homo sapiens
-
1.1.1.153 liver
-
 Homo sapiens
-
1.1.1.153 liver cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.153 1'-oxo-2'-hydroxypropyl-tetrahydropterin + NADPH + H+
-
 Homo sapiens tetrahydrobiopterin + NADP+
-
 ?
1.1.1.153 sepiapterin + NADPH + H+
-
 Homo sapiens 7,8-dihydrobiopterin + NADP+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.153 homodimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.153 SPR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.153 NADPH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.153 0.00000149
-
 pH and temperature not specified in the publication Homo sapiens QM385
1.1.1.153 0.000014
-
 pH and temperature not specified in the publication Homo sapiens sulfathiazole
1.1.1.153 0.000019
-
 pH and temperature not specified in the publication Homo sapiens sulfamethoxazole
1.1.1.153 0.0000235
-
 pH and temperature not specified in the publication Homo sapiens sulfasalazine
1.1.1.153 0.000074
-
 pH and temperature not specified in the publication Homo sapiens SPRi3
1.1.1.153 0.00029
-
 pH and temperature not specified in the publication Homo sapiens N-acetylsulfapyridine
1.1.1.153 0.00037
-
 pH and temperature not specified in the publication Homo sapiens mesalamine
1.1.1.153 0.00048
-
 pH and temperature not specified in the publication Homo sapiens sulfapyridine
1.1.1.153 0.0006
-
 pH and temperature not specified in the publication Homo sapiens dicoumarol
1.1.1.153 0.0006
-
 pH and temperature not specified in the publication Homo sapiens N-acetylserotonin
1.1.1.153 0.03
-
 pH and temperature not specified in the publication Homo sapiens Ethacrynic acid
1.1.1.153 0.03
-
 pH and temperature not specified in the publication Homo sapiens 6-Carboxypterin
1.1.1.153 0.032
-
 pH and temperature not specified in the publication Homo sapiens n-butyric acid
1.1.1.153 0.045
-
 pH and temperature not specified in the publication Homo sapiens propionic acid
1.1.1.153 0.06
-
 pH and temperature not specified in the publication Homo sapiens indomethacin
1.1.1.153 0.06
-
 pH and temperature not specified in the publication Homo sapiens rutin
1.1.1.153 0.065
-
 pH and temperature not specified in the publication Homo sapiens Isosepiapterin
1.1.1.153 0.45
-
 pH and temperature not specified in the publication Homo sapiens acetic acid

Expression

EC Number Organism Comment Expression
1.1.1.153 Homo sapiens the enzyme mRNA level increases in the brains of Parkinson's disease patients up

General Information

EC Number General Information Comment Organism
1.1.1.153 metabolism the enzyme plays an important role in the biosynthesis of tetrahydrobiopterin Homo sapiens