Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Costa, C.H.S.; Oliveira, A.R.S.; Dos Santos, A.M.; da Costa, K.S.; Lima, A.H.L.E.; Alves, C.N.; Lameira, J.
    Computational study of conformational changes in human 3-hydroxy-3-methylglutaryl coenzyme reductase induced by substrate binding (2019), J. Biomol. Struct. Dyn., 37, 4374-4383 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.34 S872D the mutation reduces the catalytic activity of the enzyme similarly to that of the phosphorylated enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.34 (R)-mevalonate + CoA + 2 NADP+ Homo sapiens
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 r
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+ Homo sapiens
-
 (R)-mevalonate + CoA + 2 NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.34 Homo sapiens P04035
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.1.1.34 phosphoprotein the enzyme is phosphorylated at Ser872 by AMP-activated protein kinase and reversibly dephosphorylated by phosphatase 2A Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.34 (R)-mevalonate + CoA + 2 NADP+
-
 Homo sapiens (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 r
1.1.1.34 (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
-
 Homo sapiens (R)-mevalonate + CoA + 2 NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.34 homotetramer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.34 3-hydroxy-3-methylglutaryl coenzyme A reductase
-
 Homo sapiens
1.1.1.34 HMG-CoA reductase
-
 Homo sapiens
1.1.1.34 HMGR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.34 NADP+
-
 Homo sapiens
1.1.1.34 NADPH
-
 Homo sapiens