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Literature summary extracted from

  • Hoda, N.; Naz, H.; Jameel, E.; Shandilya, A.; Dey, S.; Hassan, M.; Ahmad, F.; Jayaram, B.
    Curcumin specifically binds to the human calcium-calmodulin-dependent protein kinase IV Fluorescence and molecular dynamics simulation studies (2016), J. Biomol. Struct. Dyn., 34, 572-584 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.17 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.17 curcumin curcumin strongly interacts with isoform CAMK4 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.17 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.17 ATP + CREB1 protein Homo sapiens
-
 ADP + phosphorylated CREB1 protein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.17 Homo sapiens Q16566
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.17 glycoprotein the enzyme has seven glycosylation sites at Thr57, Ser58, Ser137, Ser189, Ser344, Ser345 and Ser356 Homo sapiens
2.7.11.17 phosphoprotein the enzyme has five potential phosphorylation sites at Ser12, Ser13, Thr200, Ser336 and Ser360 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.17 ammonium sulfate precipitation, NiNTA resin column chromatography, Ni-HF affinity gel filtration, and Sephacryl S-200 gel filtration Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.17 ATP + CREB1 protein
-
 Homo sapiens ADP + phosphorylated CREB1 protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.17 calcium-calmodulin-dependent protein kinase IV
-
 Homo sapiens
2.7.11.17 CAMK4
-
 Homo sapiens