EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.7.6.5 | structures of RelP in pre-catalytic state (bound to GTP and adenosine 5'-(alpha,beta-methylene)triphosphate), and post-catalytic state (bound to pppGpp). RelP forms a tetramer, but unlike RelQ (SAS1), it is strongly inhibited by both pppGpp and ppGpp and is insensitive to inhibition by RNA. The active site pocket is formed mainly by the beta-strands and the loops beta1/alpha2,alpha3/beta2, and beta3/beta4 in addition to two small helices, alpha2 and alpha5. pppGpp adopts different conformations inside the two active sites (chains A and B) of the dimer | Staphylococcus aureus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.6.5 | guanosine 3'-diphosphate 5'-diphosphate | - |
Staphylococcus aureus | |
2.7.6.5 | guanosine 3'-diphosphate 5'-triphosphate | product inhibition | Staphylococcus aureus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.6.5 | Iron | structure shows an iron-binding site at the dimer interface | Staphylococcus aureus | |
2.7.6.5 | Zinc | structure shows a putative Zn2x04-binding site | Staphylococcus aureus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.6.5 | Staphylococcus aureus | W8TMV6 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.6.5 | ATP + GTP | - |
Staphylococcus aureus | AMP + guanosine 3'-diphosphate 5'-triphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.6.5 | (p)ppGpp synthetase | - |
Staphylococcus aureus |
2.7.6.5 | RelP | - |
Staphylococcus aureus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.6.5 | 0.045 | - |
37°C, pH not specified in the publication | Staphylococcus aureus | guanosine 3'-diphosphate 5'-diphosphate | |
2.7.6.5 | 0.098 | - |
37°C, pH not specified in the publication | Staphylococcus aureus | guanosine 3'-diphosphate 5'-triphosphate |