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Literature summary extracted from

  • Libiad, M.; Motl, N.; Akey, D.L.; Sakamoto, N.; Fearon, E.R.; Smith, J.L.; Banerjee, R.
    Thiosulfate sulfurtransferase-like domain-containing 1 protein interacts with thioredoxin (2018), J. Biol. Chem., 293, 2675-2686 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.1.1 expression in Escherichia coli Homo sapiens
2.8.1.3 expression in Escherichia coli Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.8.1.1 1.04 A resolution crystal structure displays an exposed active site that is distinct from that of rhodanese and mercaptopyruvate sulfurtransferase Homo sapiens
2.8.1.3 1.04 A resolution crystal structure displays an exposed active site that is distinct from that of rhodanese and mercaptopyruvate sulfurtransferase Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.1.1 0.017
-
 thioredoxin 37°C, pH 7.4 Homo sapiens
2.8.1.1 0.27
-
 cyanide 37°C, pH 7.4 Homo sapiens
2.8.1.1 22
-
 thiosulfate cosubstrate cyanide, 37°C, pH 7.4 Homo sapiens
2.8.1.1 22
-
 thiosulfate cosubstrate thioredoxin, 37°C, pH 7.4 Homo sapiens
2.8.1.3 11
-
 glutathione 37°C, pH 7.4 Homo sapiens
2.8.1.3 17
-
 thiosulfate cosubstrate glutathione, 37°C, pH 7.4 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.1.1 cytoplasm
-
 Homo sapiens 5737
-
2.8.1.3 cytoplasm
-
 Homo sapiens 5737
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.1 Homo sapiens Q8NFU3 cf. EC 2.8.1.3
-
2.8.1.3 Homo sapiens Q8NFU3 cf. EC 2.8.1.1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.1.1 colon apical localization in colonic crypts Homo sapiens
-
2.8.1.3 colon apical localization in colonic crypts Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.1.1 2.6
-
 pH 7.4, 37°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.1 thiosulfate + 2 glutathione
-
 Homo sapiens sulfite + glutathione disulfide + sulfide
-
 ?
2.8.1.1 thiosulfate + cyanide
-
 Homo sapiens sulfite + thiocyanate
-
 ?
2.8.1.1 thiosulfate + thioredoxin
-
 Homo sapiens ?
-
 ?
2.8.1.3 thiosulfate + cyanide
-
 Homo sapiens sulfite + thiocyanate
-
 ?
2.8.1.3 thiosulfate + glutathione
-
 Homo sapiens ? + glutathione disulfide
-
 ?
2.8.1.3 thiosulfate + thioredoxin
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.1.1 TSTD1
-
 Homo sapiens
2.8.1.3 TSTD1
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.8.1.1 0.52
-
 cyanide 37°C, pH 7.4 Homo sapiens
2.8.1.3 0.43
-
 thiosulfate 37°C, pH 7.4 Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.8.1.1 1.94
-
 cyanide 37°C, pH 7.4 Homo sapiens
2.8.1.3 0.025
-
 thiosulfate 37°C, pH 7.4 Homo sapiens
2.8.1.3 0.039
-
 glutathione 37°C, pH 7.4 Homo sapiens