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Literature summary extracted from

  • Corkins, M.E.; Wilson, S.; Cocuron, J.C.; Alonso, A.P.; Bird, A.J.
    The gluconate shunt is an alternative route for directing glucose into the pentose phosphate pathway in fission yeast (2017), J. Biol. Chem., 292, 13823-13832 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.44 expression in Escherichia coli Schizosaccharomyces pombe
2.7.1.12 expression in Escherichia coli Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+ Schizosaccharomyces pombe 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?
1.1.1.44 6-phospho-D-gluconate + NADP+ Schizosaccharomyces pombe ATCC 24843 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?
2.7.1.12 ATP + D-gluconate Schizosaccharomyces pombe 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase ADP + 6-phospho-D-gluconate
-
?
2.7.1.12 ATP + D-gluconate Schizosaccharomyces pombe ATCC 24843 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase ADP + 6-phospho-D-gluconate
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.44 Schizosaccharomyces pombe P78812 the strain is lacking the zinc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that are altered by cellular zinc status
-
1.1.1.44 Schizosaccharomyces pombe ATCC 24843 P78812 the strain is lacking the zinc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that are altered by cellular zinc status
-
2.7.1.12 Schizosaccharomyces pombe Q10242 the strain is lacking the zinc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that are altered by cellular zinc status
-
2.7.1.12 Schizosaccharomyces pombe ATCC 24843 Q10242 the strain is lacking the zinc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that are altered by cellular zinc status
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.44
-
Schizosaccharomyces pombe
2.7.1.12
-
Schizosaccharomyces pombe

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.44 6-phospho-D-gluconate + NADP+
-
Schizosaccharomyces pombe D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?
1.1.1.44 6-phospho-D-gluconate + NADP+ 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?
1.1.1.44 6-phospho-D-gluconate + NADP+
-
Schizosaccharomyces pombe ATCC 24843 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?
1.1.1.44 6-phospho-D-gluconate + NADP+ 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe ATCC 24843 D-ribulose 5-phosphate + CO2 + NADPH + H+
-
?
2.7.1.12 ATP + D-gluconate
-
Schizosaccharomyces pombe ADP + 6-phospho-D-gluconate
-
?
2.7.1.12 ATP + D-gluconate 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe ADP + 6-phospho-D-gluconate
-
?
2.7.1.12 ATP + D-gluconate
-
Schizosaccharomyces pombe ATCC 24843 ADP + 6-phospho-D-gluconate
-
?
2.7.1.12 ATP + D-gluconate 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe ATCC 24843 ADP + 6-phospho-D-gluconate
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.44 6-phosphogluconate dehydrogenase 1
-
Schizosaccharomyces pombe
1.1.1.44 GCG1
-
Schizosaccharomyces pombe
2.7.1.12 Idn1 gluconate kinase
-
Schizosaccharomyces pombe

General Information

EC Number General Information Comment Organism
1.1.1.44 metabolism 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe
2.7.1.12 metabolism 6-phosphogluconate dehydrogenase (Gcd1) and gluconate kinase (Idn1) act together to shunt glucose into the pentose phosphate pathway, creating an alternative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and the rate-limiting enzyme glucose-6-phosphate dehydrogenase Schizosaccharomyces pombe