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Literature summary extracted from

  • Yadav, P.K.; Rajasekharan, R.
    Misregulation of a DDHD domain-containing lipase causes mitochondrial dysfunction in yeast (2016), J. Biol. Chem., 291, 18562-18581 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.118 expressed in Escherichia coli BL21(DE3) cells Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.118 G499A the mutant shows reduced activity compared to the wild type enzyme Saccharomyces cerevisiae
3.1.1.118 G503A the mutant shows reduced activity compared to the wild type enzyme Saccharomyces cerevisiae
3.1.1.118 S501A inactive Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.118 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.118 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.118 Ni-NTA column chromatography Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.118 1,2-dioleoyl-sn-glycero-3-phospho-(1-rac-glycerol) + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phospho-(1-rac-glycerol) + oleate
-
 ?
3.1.1.118 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phosphoethanolamine + oleate
-
 ?
3.1.1.118 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1-racglycerol) + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phospho-(1-rac-glycerol) + palmitate
-
 ?
3.1.1.118 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phosphoethanolamine + palmitate
-
 ?
3.1.1.118 1-stearoyl-2-oleoyl-sn-glycero-3-phospho-(1-rac-glycerol) + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phospho-(1-rac-glycerol) + stearate
-
 ?
3.1.1.118 1-stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Saccharomyces cerevisiae 2-oleoyl-sn-glycero-3-phosphoethanolamine + stearate
-
 ?
3.1.1.118 cardiolipin + H2O
-
 Saccharomyces cerevisiae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.118 ? x * 80000, SDS-PAGE Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
3.1.1.118 DDHD domaincontaining lipase 1
-
 Saccharomyces cerevisiae
3.1.1.118 DDL1
-
 Saccharomyces cerevisiae
3.1.1.118 PA-PLA1
-
 Saccharomyces cerevisiae
3.1.1.118 Yor022c
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
3.1.1.118 malfunction the misregulation of the enzyme gene by Aft1/2 transcription factors alters cardiolipin metabolism and causes mitochondrial dysfunction in the cells Saccharomyces cerevisiae