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Literature summary extracted from

  • Roje, S.; Wang, H.; McNeil, S.D.; Raymond, R.K.; Appling, D.R.; Shachar-Hill, Y.; Bohnert, H.J.; Hanson, A.D.
    Isolation, characterization, and functional expression of cDNAs encoding NADH-dependent methylenetetrahydrofolate reductase from higher plants (1999), J. Biol. Chem., 274, 36089-36096 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.5.1.54 S-adenosyl-L-methionine stimulation by 10-20% Arabidopsis thaliana
1.5.1.54 S-adenosyl-L-methionine stimulation by 50-70% Arabidopsis thaliana

General Stability

EC Number General Stability Organism
1.5.1.54 unstable, loss of 50% of activity during 30 min on ice Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.54 additional information not inhibitory: S-Methyl-L-methionine; not inhibitory: S-Methyl-L-methionine Arabidopsis thaliana
1.5.1.54 additional information not inhibitory: S-adenosyl-L-methionine and S-Methyl-L-methionine Zea mays

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.54 Arabidopsis thaliana O80585 isoform MTHFR2, cf. EC 1.5.1.20
-
1.5.1.54 Arabidopsis thaliana Q9SE60 isoform MTHFR1, cf. EC 1.5.1.20
-
1.5.1.54 Zea mays Q9SE94 cf. EC 1.5.1.20
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.54 6.9
-
pH 7.2, 30°C Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.54 5,10-methylenetetrahydrofolate + menadiol
-
Zea mays 5-methyltetrahydrofolate + menadione
-
r
1.5.1.54 5,10-methylenetetrahydrofolate + menadiol
-
Arabidopsis thaliana 5-methyltetrahydrofolate + menadione
-
r
1.5.1.54 5,10-methylenetetrahydrofolate + NADH + H+
-
Zea mays 5-methyltetrahydrofolate + NAD+
-
?
1.5.1.54 5,10-methylenetetrahydrofolate + NADH + H+
-
Arabidopsis thaliana 5-methyltetrahydrofolate + NAD+
-
?
1.5.1.54 5-methyltetrahydrofolate + menadione
-
Zea mays 5,10-methylenetetrahydrofolate + menadiol
-
r
1.5.1.54 5-methyltetrahydrofolate + menadione
-
Arabidopsis thaliana 5,10-methylenetetrahydrofolate + menadiol
-
r

Subunits

EC Number Subunits Comment Organism
1.5.1.54 ? x * 66300, calculated from sequence and SDS-PAGE Arabidopsis thaliana
1.5.1.54 ? x * 66800, calculated from sequence Arabidopsis thaliana

Synonyms

EC Number Synonyms Comment Organism
1.5.1.54 MTHFR1
-
Arabidopsis thaliana
1.5.1.54 MTHFR2
-
Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.54 NADH enzyme strongly prefers NADH over NADPH Zea mays
1.5.1.54 NADH enzyme strongly prefers NADH over NADPH Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
1.5.1.54 physiological function enzyme is able to complement a Saccharomyces cerevisiae met12 met13 double disruptant Zea mays
1.5.1.54 physiological function enzyme is able to complement a Saccharomyces cerevisiae met12 met13 double disruptant Arabidopsis thaliana