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Literature summary extracted from

  • Li, T.; Liu, G.S.; Zhou, W.; Jiang, M.; Ren, Y.H.; Tao, X.Y.; Liu, M.; Zhao, M.; Wang, F.Q.; Gao, B.; Wei, D.Z.
    Metabolic engineering of Saccharomyces cerevisiae to overproduce squalene (2020), J. Agric. Food Chem., 68, 2132-2138 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.88 expressed in Saccharomyces cerevisiae strain SE5 Ruegeria pomeroyi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.88 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ Ruegeria pomeroyi the enzyme is highly specific for NADH (R)-mevalonate + CoA + 2 NAD+
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Organism

EC Number Organism UniProt Comment Textmining
1.1.1.88 Ruegeria pomeroyi
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.88 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ the enzyme is highly specific for NADH Ruegeria pomeroyi (R)-mevalonate + CoA + 2 NAD+
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Synonyms

EC Number Synonyms Comment Organism
1.1.1.88 3-hydroxy-3-methylglutaryl-coenzyme-A reductase
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Ruegeria pomeroyi
1.1.1.88 HMG-CoA reductase
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Ruegeria pomeroyi
1.1.1.88 NADH-HMGR
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Ruegeria pomeroyi

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.88 NAD+
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Ruegeria pomeroyi