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Literature summary extracted from

  • Fazio, A.; Obeng, E.; Rusciano, I.; Marvi, M.; Zoli, M.; Mongiorgi, S.; Ramazzotti, G.; Follo, M.; McCubrey, J.; Cocco, L.; Manzoli, L.; Ratti, S.
    Subcellular localization relevance and cancer-associated mechanisms of diacylglycerol kinases (2020), Int. J. Mol. Sci., 21, 1-19 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.107 5-[(2E)-3-(2-furyl)prop-2-enylidene]-3-[(phenylsulfonyl)amino]2-thioxo-1,3-thiazolidin-4-one
-
 Homo sapiens
2.7.1.107 R59022 i.e. 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one Homo sapiens
2.7.1.107 R59949 i.e. 3-[2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl]-2, 3-dihydro-2-thioxo-4(1H)quinazolinone Homo sapiens
2.7.1.107 ritanserin
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.107 cytosol
-
 Homo sapiens 5829
-
2.7.1.107 endoplasmic reticulum
-
 Homo sapiens 5783
-
2.7.1.107 endosome
-
 Homo sapiens 5768
-
2.7.1.107 Golgi apparatus
-
 Homo sapiens 5794
-
2.7.1.107 nucleus
-
 Homo sapiens 5634
-
2.7.1.107 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Homo sapiens
-
 ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Homo sapiens O75912
-
-
2.7.1.107 Homo sapiens P23743
-
-
2.7.1.107 Homo sapiens P49619
-
-
2.7.1.107 Homo sapiens P52429
-
-
2.7.1.107 Homo sapiens P52824
-
-
2.7.1.107 Homo sapiens Q13574
-
-
2.7.1.107 Homo sapiens Q16760
-
-
2.7.1.107 Homo sapiens Q5KSL6
-
-
2.7.1.107 Homo sapiens Q86XP1
-
-
2.7.1.107 Homo sapiens Q9Y6T7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 acute myeloid leukemia cell
-
 Homo sapiens
-
2.7.1.107 breast cancer cell
-
 Homo sapiens
-
2.7.1.107 cervical carcinoma cell
-
 Homo sapiens
-
2.7.1.107 colonic cancer cell
-
 Homo sapiens
-
2.7.1.107 colorectal cancer cell
-
 Homo sapiens
-
2.7.1.107 glioblastoma cell
-
 Homo sapiens
-
2.7.1.107 hepatoma cell
-
 Homo sapiens
-
2.7.1.107 lung adenocarcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
 Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 DGKalpha isoform Homo sapiens
2.7.1.107 DGKbeta isoform Homo sapiens
2.7.1.107 DGKdelta isoform Homo sapiens
2.7.1.107 DGKepsilon isoform Homo sapiens
2.7.1.107 DGKeta isoform Homo sapiens
2.7.1.107 DGKgamma isoform Homo sapiens
2.7.1.107 DGKiota isoform Homo sapiens
2.7.1.107 DGKkappa isoform Homo sapiens
2.7.1.107 DGKtheta isoform Homo sapiens
2.7.1.107 DGKzeta isoform Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.107 physiological function enzyme isoforms control cancer cell survival, proliferation, and angiogenesis by regulating Akt/mTOR and MAPK/ERK pathways. In addition, some enzyme isoforms control cancer cell migration by regulating the activities of the Rho GTPases Rac1 and RhoA Homo sapiens