Literature summary extracted from

Khan, M.S.; Qais, F.A.; Rehman, M.T.; Ismail, M.H.; Alokail, M.S.; Altwaijry, N.; Alafaleq, N.O.; AlAjmi, M.F.; Salem, N.; Alqhatani, R.
Mechanistic inhibition of non-enzymatic glycation and aldose reductase activity by naringenin Binding, enzyme kinetics and molecular docking analysis (2020), Int. J. Biol. Macromol., 159, 87-97 .

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.21	naringenin	uncompetitive. The interaction is enthalpy driven and the microenvironment of aromatic residues is also altered. Naringenin inhibits fructosamine content by approximately 31.6% at 0.01 mM, and more than 93% inhibition of fluorescent advanced glycation end-products is achieved. Naringenin forms hydrogen bonds (Asn160 and Ile260), and two Pi-Pi interactions with Trp20 and one with His110	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.21	Homo sapiens	P15121	-	-

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
1.1.1.21	0.0026	-	pH 6.2, 25°C	Homo sapiens	naringenin

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Release 2023.1 (January 2023)