Literature summary extracted from

Lv, M.; Zhang, D.; Dai, D.; Zhang, W.; Zhang, L.
Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion (2016), Inflamm. Res., 65, 551-562 .

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.1.91	PF-543	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.7.1.91	ATP + sphingosine	Rattus norvegicus	-	ADP + sphingosine 1-phosphate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.91	Rattus norvegicus	Q91V26	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.91	microglia	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.91	ATP + sphingosine	-	Rattus norvegicus	ADP + sphingosine 1-phosphate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.1.91	sphingosine kinase 1	-	Rattus norvegicus
2.7.1.91	SPHK1	isoform	Rattus norvegicus

Expression

EC Number	Organism	Comment	Expression
2.7.1.91	Rattus norvegicus	enzyme expression is increased in microglia subjected to oxygen-glucose deprivation	up

General Information

EC Number	General Information	Comment	Organism
2.7.1.91	physiological function	the enzyme regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion	Rattus norvegicus

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Release 2023.1 (January 2023)