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Literature summary extracted from

  • Lin, D.; Fan, J.; Wang, J.; Liu, L.; Xu, L.; Li, F.; Yang, J.; Li, B.
    The fructose-specific phosphotransferase system of Klebsiella pneumoniae is regulated by global regulator CRP and linked to virulence and growth (2018), Infect. Immun., 86, e00340-18 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.202 membrane
-
 Klebsiella pneumoniae 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.202 [protein]-Npi-phospho-L-histidine + D-fructose[side 1] Klebsiella pneumoniae
-
 [protein]-L-histidine + D-fructose 1-phosphate[side 2]
-
 ?
2.7.1.202 [protein]-Npi-phospho-L-histidine + D-fructose[side 1] Klebsiella pneumoniae NTUH-2044
-
 [protein]-L-histidine + D-fructose 1-phosphate[side 2]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.202 Klebsiella pneumoniae
-
-
-
2.7.1.202 Klebsiella pneumoniae NTUH-2044
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.202 [protein]-Npi-phospho-L-histidine + D-fructose[side 1]
-
 Klebsiella pneumoniae [protein]-L-histidine + D-fructose 1-phosphate[side 2]
-
 ?
2.7.1.202 [protein]-Npi-phospho-L-histidine + D-fructose[side 1]
-
 Klebsiella pneumoniae NTUH-2044 [protein]-L-histidine + D-fructose 1-phosphate[side 2]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.202 fructose-specific enzyme IIC
-
 Klebsiella pneumoniae
2.7.1.202 fructose-specific phosphotransferase system
-
 Klebsiella pneumoniae
2.7.1.202 frwC
-
 Klebsiella pneumoniae

General Information

EC Number General Information Comment Organism
2.7.1.202 malfunction enzyme gene frwC deletion can enhance biofilm formation and capsular polysaccharide biosynthesis but decreases the growth rate and lethality in mice Klebsiella pneumoniae
2.7.1.202 physiological function frwC gene expression is controlled by cyclic AMP receptor protein directly and that such regulation contributes to bacterial growth, capsular polysaccharide synthesis, and the virulence of the cyclic AMP receptor protein-deficient strain Klebsiella pneumoniae