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Literature summary extracted from

  • Tag-El-Din-Hassan, H.T.; Morimatsu, M.; Agui, T.
    Functional analysis of duck, goose, and ostrich 2'-5'-oligoadenylate synthetase (2018), Infect. Genet. Evol., 62, 220-232 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.84 gene N308_13623, DNA and amino acid sequence determination and analysis, sequence comparisons of avian OASL enzymes, phylogenetic analysis, recombinant expression of EGFP-tagged enzyme in HEK-293FT and BHK-21 cells Struthio camelus australis
2.7.7.84 gene OAS-L, DNA and amino acid sequence determination and analysis, sequence comparisons of avian OASL enzymes, phylogenetic analysis, recombinant expression of EGFP-tagged enzyme in HEK-293FT and BHK-21 cells Anas platyrhynchos
2.7.7.84 gene OAS-L, DNA and amino acid sequence determination and analysis, sequence comparisons of avian OASL enzymes, phylogenetic analysis, recombinant expression of EGFP-tagged enzyme in HEK-293FT and BHK-21 cells Anser cygnoides
2.7.7.84 gene OASL, DNA and amino acid sequence determination and analysis, sequence comparisons of avian OASL enzymes, phylogenetic analysis, recombinant expression of EGFP-tagged enzyme in HEK-293FT and BHK-21 cells Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.84 Mg2+ required Anas platyrhynchos
2.7.7.84 Mg2+ required Anser cygnoides
2.7.7.84 Mg2+ required Struthio camelus australis
2.7.7.84 Mg2+ required Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.84 3 ATP Anas platyrhynchos
-
 pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?
2.7.7.84 3 ATP Anser cygnoides
-
 pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?
2.7.7.84 3 ATP Struthio camelus australis
-
 pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?
2.7.7.84 3 ATP Gallus gallus
-
 pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.84 Anas platyrhynchos A0A1B1V538
-
-
2.7.7.84 Anser cygnoides A0A1B1V537
-
-
2.7.7.84 Gallus gallus H9L0X6
-
-
2.7.7.84 Struthio camelus australis A0A093JNH5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.84 3 ATP
-
 Anas platyrhynchos pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?
2.7.7.84 3 ATP
-
 Anser cygnoides pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?
2.7.7.84 3 ATP
-
 Struthio camelus australis pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?
2.7.7.84 3 ATP
-
 Gallus gallus pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?
2.7.7.84 additional information enzyme chOASL possesses the enzymatic activity to convert the ATP to 2'-5'-A up to tetramer Gallus gallus ?
-
-
2.7.7.84 additional information enzyme duOASL possesses the enzymatic activity to convert the ATP to 2'-5'-A up to tetramer Anas platyrhynchos ?
-
-
2.7.7.84 additional information enzyme goOASL possesses the enzymatic activity to convert the ATP to 2'-5'-A up to tetramer Anser cygnoides ?
-
-
2.7.7.84 additional information enzyme osOASL possesses the enzymatic activity to convert the ATP to 2'-5'-A up to tetramer, very low activity Struthio camelus australis ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.7.84 2'-5'-oligoadenylate synthetase
-
 Anas platyrhynchos
2.7.7.84 2'-5'-oligoadenylate synthetase
-
 Anser cygnoides
2.7.7.84 2'-5'-oligoadenylate synthetase
-
 Struthio camelus australis
2.7.7.84 2'-5'-oligoadenylate synthetase
-
 Gallus gallus
2.7.7.84 chOASL
-
 Gallus gallus
2.7.7.84 duOASL
-
 Anas platyrhynchos
2.7.7.84 goOASL
-
 Anser cygnoides
2.7.7.84 N308_13623
-
 Struthio camelus australis
2.7.7.84 OAS
-
 Anas platyrhynchos
2.7.7.84 OAS
-
 Anser cygnoides
2.7.7.84 OAS
-
 Struthio camelus australis
2.7.7.84 OAS
-
 Gallus gallus
2.7.7.84 OAS-L
-
 Anas platyrhynchos
2.7.7.84 OAS-L
-
 Anser cygnoides
2.7.7.84 OAS3
-
 Struthio camelus australis
2.7.7.84 OASL
-
 Gallus gallus
2.7.7.84 osOAS1
-
 Struthio camelus australis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.84 30
-
 assay at Anas platyrhynchos
2.7.7.84 30
-
 assay at Anser cygnoides
2.7.7.84 30
-
 assay at Struthio camelus australis
2.7.7.84 30
-
 assay at Gallus gallus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.84 7.4
-
 assay at Anas platyrhynchos
2.7.7.84 7.4
-
 assay at Anser cygnoides
2.7.7.84 7.4
-
 assay at Struthio camelus australis
2.7.7.84 7.4
-
 assay at Gallus gallus

General Information

EC Number General Information Comment Organism
2.7.7.84 physiological function the enzyme shows inhibitory activity on WNV replicon replication Anas platyrhynchos
2.7.7.84 physiological function the enzyme shows inhibitory activity on WNV replicon replication Anser cygnoides
2.7.7.84 physiological function the enzyme shows inhibitory activity on WNV replicon replication Struthio camelus australis
2.7.7.84 physiological function the enzyme shows inhibitory activity on WNV replicon replication Gallus gallus