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Literature summary extracted from

  • Liu, N.; Wang, Z.; Cheng, Y.; Zhang, P.; Wang, X.; Yang, H.; Liu, H.; Zhang, Y.; Tu, Y.
    Acylglycerol kinase functions as an oncogene and an unfavorable prognostic marker of human gliomas (2016), Hum. Pathol., 58, 105-112 .
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.94 medicine high enzyme expression is significantly associated with the grade of malignancy and poor prognosis in glioma patients. The enzyme is a therapeutic target for treatment of glioma Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.94 ATP + acylglycerol Homo sapiens
-
ADP + lysophosphatidic acid
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.94 Homo sapiens Q53H12
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.94 glioma cell
-
Homo sapiens
-
2.7.1.94 U-251MG cell
-
Homo sapiens
-
2.7.1.94 U-87MG cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.94 ATP + acylglycerol
-
Homo sapiens ADP + lysophosphatidic acid
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.94 AGK
-
Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.94 Homo sapiens enzyme expression, at both mRNA and protein levels, are markedly upregulated in glioma tissues compared with non-neoplastic brain tissues up

General Information

EC Number General Information Comment Organism
2.7.1.94 malfunction silencing the expression of the enzyme dramatically suppresses cell proliferation, migration and invasion of glioma cells in vitro Homo sapiens
2.7.1.94 physiological function the enzyme plays an important role in the viability and motility of glioma cells. Enzyme upregulation is involved into glioma development and progression Homo sapiens