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Literature summary extracted from

  • Dean, D.; Maroja, L.; Cottrill, S.; Bomkamp, B.; Westervelt, K.; Deitcher, D.
    The wavy mutation maps to the inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) gene of drosophila and interacts with IP3R to affect wing development (2016), G3 (Bethesda), 6, 299-310 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.127 gene wavy, DNA and amino acid sequence determination and analysis, detailed analysis of genetic organization, overview Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.127 additional information mutant alleles of wavy (wy), a classic locus of the fruit fly Drosophila melanogaster, map to IP3 3-kinase 2 (IP3K2), mapping of the wy locus. Mutations in wy disrupt wing structure in a highly specific pattern, wy alleles, mapping, complementation tests, RNAi experiments of IP3K2 (using VDRC v19159: P(GD8778)v19159/TM3 Sb), phenotype analysis, overview. All three mutant alleles of wy are dominantly suppressed by both mutant alleles of IP3R Drosophila melanogaster

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Mg2+ required Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Drosophila melanogaster
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 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Drosophila melanogaster A0A0U2TSJ5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Drosophila melanogaster ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.127 IP3 3-kinase 2
-
 Drosophila melanogaster
2.7.1.127 IP3K2
-
 Drosophila melanogaster
2.7.1.127 wavy
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.7.1.127 evolution enzyme IP3 3-kinase 2 (IP3K2) is a member of the inositol polyphosphate kinase gene family Drosophila melanogaster
2.7.1.127 malfunction mutant alleles of wavy (wy), a classic locus of the fruit fly Drosophila melanogaster, map to IP3 3-kinase 2 (IP3K2). Mutations in wy disrupt wing structure in a highly specific pattern. RNAi experiments using GAL4 and GAL80ts. Gradations in the severity of the wy phenotype provide high-resolution readouts of IP3K2 function and of overall IP3 signaling are analyzed. A dominant modifier screen reveals that mutations in IP3R strongly suppress the wy phenotype, suggesting that the wy phenotype results from reduced IP4 levels, and/or excessive IP3R signaling. Potential models for how IP3K2 affects wing morphology and how mutations in IP3R dominantly suppress the wy phenotype, modeling the interactions between wavy and IP3R, overview Drosophila melanogaster
2.7.1.127 metabolism inositol 1,4,5-trisphosphate (IP3) regulates a host of biological processes from egg activation to cell death. When IP3-specific receptors (IP3Rs) bind to IP3, they release calcium from the ER into the cytoplasm, triggering a variety of cell type- and developmental stage-specific responses. Alternatively, inositol polyphosphate kinases can phosphorylate IP3. This limits IP3R activation by reducing IP3 levels, and also generates new signaling molecules altogether. The divergent pathways draw from the same IP3 pool yet cause very different cellular responses. Controlling the relative rates of IP3R activation vs. phosphorylation of IP3 is essential for proper cell functioning. Modeling the interactions between wavy and IP3R Drosophila melanogaster
2.7.1.127 physiological function IP3K2 function is required in the wing discs of early pupae for normal wing development. Controlling the relative rates of IP3R activation vs. phosphorylation of IP3 is essential for proper cell functioning. IP3K2 function is required in the developing wing blade during early pupal life Drosophila melanogaster