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Literature summary extracted from

  • Cheng, Y.; Yang, Y.; Wu, Y.; Wang, W.; Xiao, L.; Zhang, Y.; Tang, J.; Huang, Y.D.; Zhang, S.; Xiang, Q.
    The curcumin derivative, H10, suppresses hormone-dependent prostate cancer by inhibiting 17beta-hydroxysteroid dehydrogenase type 3 (2020), Front. Pharmacol., 11, 637 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.64 LC540 cells stably overexpress the enzyme (17beta-HSD3) Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.64 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.64 androstenedione + NADPH + H+ Homo sapiens
-
 testosterone + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.64 Homo sapiens P37058
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.64 LC-540 cell stably overexpress 17beta-HSD3 Homo sapiens
-
1.1.1.64 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.64 androstenedione + NADPH + H+
-
 Homo sapiens testosterone + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.64 17beta-HSD3
-
 Homo sapiens
1.1.1.64 17beta-hydroxysteroid dehydrogenase type 3
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.1.1.64 Homo sapiens curcumin analog H10 inhibits the production of 17beta-HSD3 in vitro. It has no effect on the expression levels of 17beta-HSD3, 3betaHSD1, CYP17alpha1, CYP11alpha1, and STAR. H10 could serve as an effective inhibitor of 17beta-HSD3, which in turn would inhibit the biosynthesis of androgens and progression of prostate cancer down

General Information

EC Number General Information Comment Organism
1.1.1.64 drug target the enzyme is a potential therapeutic target for hormone-dependent prostate cancer Homo sapiens
1.1.1.64 metabolism last step of testosterone biosynthesis Homo sapiens