Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Min, B.; Park, S.; Kang, H.; Kim, D.; Ham, H.; Ha, C.; Choi, B.; Lee, J.; Oh, C.; Yoo, E.; Kim, H.; Kim, B.; Jeon, J.; Hyeon, D.; Hwang, D.; Kim, Y.; Lee, C.; Lee, T.; Jungwhan, K.; Choi, Y.; Park, K.; Chawla, A.; Lee, J.; Harris, R.; Lee, I.
    Pyruvate dehydrogenase kinase is a metabolic checkpoint for polarization of macrophages to the M1 phenotype (2019), Front. Immunol., 10, 944 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.2 Dichloroacetate
-
 Mus musculus
2.7.11.2 KPLH1130
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (acetyl-transferring)] Mus musculus
-
 ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.2 Mus musculus O70571
-
-
2.7.11.2 Mus musculus Q9JK42
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.2 ATP + [pyruvate dehydrogenase (acetyl-transferring)]
-
 Mus musculus ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.2 PDK2 isoform Mus musculus
2.7.11.2 PDK4 isoform Mus musculus
2.7.11.2 pyruvate dehydrogenase kinase
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.11.2 malfunction isoform PDK2 deletion or inhibition prevents polarization of macrophages to the M1 phenotype in response to inflammatory stimuli (lipopolysaccharide plus interferon gamma). Global isoform PDK2 deficiency in high fat diet-fed mice reduces insulin resistance and adipose tissue inflammation Mus musculus
2.7.11.2 malfunction isoform PDK4 deletion or inhibition prevents polarization of macrophages to the M1 phenotype in response to inflammatory stimuli (lipopolysaccharide plus interferon gamma). Global isoform PDK4 deficiency in high fat diet-fed mice reduces insulin resistance and adipose tissue inflammation Mus musculus
2.7.11.2 physiological function enzyme isoform PDK2 is a metabolic checkpoint for polarization of macrophages to the M1 phenotype Mus musculus
2.7.11.2 physiological function enzyme isoform PDK4 is a metabolic checkpoint for polarization of macrophages to the M1 phenotype Mus musculus