Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Campbell, J.C.; VanSchouwen, B.; Lorenz, R.; Sankaran, B.; Herberg, F.W.; Melacini, G.; Kim, C.
    Crystal structure of cGMP-dependent protein kinase Ib cyclic nucleotide-binding-B domain Rp-cGMPS complex reveals an apo-like, inactive conformation (2017), FEBS Lett., 591, 221-230 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.12 cGMP activation constant (Ka) of 537 nM Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.11.12 cGMP-dependent protein kinase Ib cyclic nucleotide-binding domain, hanging drop vapor diffusion method, using 0.8 M lithium sulfate monohydrate, 0.1 M sodium acetate trihydrate, pH 4.0, 4% (v/v) polyethylene glycol 200 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.12 additional information the R-diastereomer of the phosphorothioate analog of cGMP, Rp-cGMPS, inhibits enzyme isoform PKG I by stabilizing the inactive conformation of cyclic nucleotide-binding domain Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.12 Mg2+ 10 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.12 ATP + Kemptide Homo sapiens
-
 ADP + Kemptide phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.12 Homo sapiens Q13976
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.12 ATP + Kemptide
-
 Homo sapiens ADP + Kemptide phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.12 cGMP-dependent protein kinase Ib
-
 Homo sapiens
2.7.11.12 PKG Ibeta
-
 Homo sapiens