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Literature summary extracted from

  • Degwert, N.; Latuske, E.; Vohwinkel, G.; Stamm, H.; Klokow, M.; Bokemeyer, C.; Fiedler, W.; Wellbrock, J.
    Deoxycytidine kinase is downregulated under hypoxic conditions and confers resistance against cytarabine in acute myeloid leukaemia (2016), Eur. J. Haematol., 97, 239-244 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens P27707
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 acute myeloid leukemia cell
-
 Homo sapiens
-
2.7.1.74 HL-60 cell
-
 Homo sapiens
-
2.7.1.74 Kasumi-1 cell
-
 Homo sapiens
-
2.7.1.74 KG-1 cell
-
 Homo sapiens
-
2.7.1.74 MOLM-13 cell
-
 Homo sapiens
-
2.7.1.74 MV-4-11 cell
-
 Homo sapiens
-
2.7.1.74 OCI-AML5 cell
-
 Homo sapiens
-
2.7.1.74 OCI-M1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 NTP + cytarabine
-
 Homo sapiens NDP + cytarabine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.74 Homo sapiens the enzyme is downregulated under hypoxic conditions down

General Information

EC Number General Information Comment Organism
2.7.1.74 physiological function the enzyme confers resistance against cytarabine in acute myeloid leukaemia Homo sapiens