EC Number | Cloned (Comment) | Organism |
---|---|---|
2.8.2.1 | expression in HeLa cell, SKN-MC cell, and SH-SY5Y cell | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.8.2.1 | additional information | mutation of isoforms SULT1A1 and SULT1A3 to the sequence found in mouse Sult1e1, which does not form homodimers (T269P, V270E). Mutants bind neither to SULT4A1 nor to each other | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.8.2.1 | Homo sapiens | P0DMM9 | isoform SULT1A3 | - |
2.8.2.1 | Homo sapiens | P50225 | isoform SULT1A1 | - |
2.8.2.1 | Homo sapiens | Q9BR01 | isoform SULT4A1 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.8.2.1 | neuron | isoforms SULT4A1 and SULT1A1/3 colocalize in brain neurons | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.8.2.1 | 3'-phosphoadenylyl sulfate + dopamine | - |
Homo sapiens | adenosine 3',5'-bisphosphate + dopamine sulfate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.8.2.1 | More | isoforms SULT4A1, SULT1A1, and SULT1A3 form homodimers and heterodimers that require the sulfotransferase dimerization motif | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.8.2.1 | SULT1A1 | - |
Homo sapiens |
2.8.2.1 | SULT1A3 | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.8.2.1 | metabolism | isoform SULT4A1 interacts with both SULT1A1 and SULT1A3 when expressed in human cells. SULT4A1, SULT1A1, and SULT1A3 proteins form homodimers and heterodimers that require the sulfotransferase dimerization motif. A loss in SULT1A1/3 protein but an increase in SULT4A1 protein is observed during differentiation of neuronal SH-SY5Y cells, resulting in an increase in the toxicity of substrate dopamine | Homo sapiens |