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Literature summary extracted from

  • Hussey, M.; Holleran, G.; Smith, S.; Sherlock, M.; McNamara, D.
    The role and regulation of the 11 beta-hydroxysteroid dehydrogenase enzyme system in patients with inflammatory bowel disease (2017), Digest. Dis. Sci., 62, 3385-3390 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisol + NAD+ Homo sapiens the reaction is catalyzed by isoform 11beta-HSD2 cortisone + NADH + H+
-
 ?
1.1.1.146 cortisone + NADPH + H+ Homo sapiens the reaction is catalyzed by isoform 11beta-HSD1 cortisol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens P28845
-
-
1.1.1.146 Homo sapiens P80365
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 colon colonic tissue from inflammatory bowel disease patients and healthy controls Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisol + NAD+ the reaction is catalyzed by isoform 11beta-HSD2 Homo sapiens cortisone + NADH + H+
-
 ?
1.1.1.146 cortisone + NADPH + H+ the reaction is catalyzed by isoform 11beta-HSD1 Homo sapiens cortisol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD1 isoform Homo sapiens
1.1.1.146 11beta-HSD2 isoform Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NAD+
-
 Homo sapiens
1.1.1.146 NADPH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.1.1.146 Homo sapiens isoform 11beta-HSD2 expression is downregulated in patients with inflammatory bowel disease compared with controls down
1.1.1.146 Homo sapiens isoform 11beta-HSD1 expression does not vary in patients with inflammatory bowel disease compared with controls additional information