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Literature summary extracted from
- Expression and activity of the cortisol-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 is tissue and species-specific (2019), Chem. Biol. Interact., 303, 57-61 .
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.146 | carbenoxolone | - |
Homo sapiens |  |
| 1.1.1.146 | epigallocatechin gallate | - |
Homo sapiens | |
| 1.1.1.146 | glycyrrhetinic acid | - |
Homo sapiens | |
| 1.1.1.146 | Momordica charantia extract | - |
Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.146 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| 1.1.1.146 | microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.146 | cortisone + NADPH + H+ | Homo sapiens | - |
cortisol + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.146 | Homo sapiens | P28845 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.146 | adipose tissue | - |
Homo sapiens | - |
| 1.1.1.146 | brain | - |
Homo sapiens | - |
| 1.1.1.146 | heart | - |
Homo sapiens | - |
| 1.1.1.146 | inflammatory cell | - |
Homo sapiens | - |
| 1.1.1.146 | leukocyte | - |
Homo sapiens | - |
| 1.1.1.146 | liver | highest expression | Homo sapiens | - |
| 1.1.1.146 | ovary | - |
Homo sapiens | - |
| 1.1.1.146 | skeletal muscle | - |
Homo sapiens | - |
| 1.1.1.146 | testis | - |
Homo sapiens | - |
| 1.1.1.146 | uterus | - |
Homo sapiens | - |
| 1.1.1.146 | vasculature | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.146 | cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.146 | 11beta-HSD type 1 | - |
Homo sapiens |
| 1.1.1.146 | 11beta-HSD1 | - |
Homo sapiens |
| 1.1.1.146 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.146 | NADPH | dependent on | Homo sapiens | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.1.1.146 | physiological function | the enzyme plays important roles in the development of the metabolic syndrome as well as at the interface of inflammation and obesity | Homo sapiens |
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Release 2023.1 (January 2023)
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