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Literature summary extracted from

  • Moschini, R.; Rotondo, R.; Renzone, G.; Balestri, F.; Cappiello, M.; Scaloni, A.; Mura, U.; Del-Corso, A.
    Kinetic features of carbonyl reductase 1 acting on glutathionylated aldehydes (2017), Chem. Biol. Interact., 276, 127-132 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.184 daidzein 71% residual activity at 0.05 mM Homo sapiens
1.1.1.184 daidzin 74% residual activity at 0.05 mM Homo sapiens
1.1.1.184 genistein 63% residual activity at 0.05 mM Homo sapiens
1.1.1.184 quercetin
-
Homo sapiens
1.1.1.184 quercitrin
-
Homo sapiens
1.1.1.184 rutin
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.184 0.0046
-
9,10-phenantrenequinone at pH 8.4 and 37°C Homo sapiens
1.1.1.184 0.0065
-
glutathionyl-nonanal at pH 8.4 and 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.184 Homo sapiens P16152
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.184
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.184 3-glutathionyl-4-hydroxynonanal + NADPH + H+
-
Homo sapiens 3-glutathionyl-1,4-dihydroxynonane + NADP+
-
?
1.1.1.184 3-glutathionyl-4-hydroxynonanal hemiacetal + NADPH + H+
-
Homo sapiens 3-glutathionyl-gamma-nonanolactone + NADP+
-
?
1.1.1.184 4-hydroxy-2-hexenal + NADPH + H+
-
Homo sapiens ?
-
?
1.1.1.184 9,10-phenantrenequinone + NADPH + H+
-
Homo sapiens ?
-
?
1.1.1.184 glutathionyl-nonanal + NADPH + H+
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.184 carbonyl reductase 1
-
Homo sapiens
1.1.1.184 CBR1
-
Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.184 30.8
-
glutathionyl-nonanal at pH 8.4 and 37°C Homo sapiens
1.1.1.184 66.7
-
9,10-phenantrenequinone at pH 8.4 and 37°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.184 0.00074
-
at pH 8.4 and 37°C Homo sapiens rutin
1.1.1.184 0.00165
-
at pH 8.4 and 37°C Homo sapiens quercetin
1.1.1.184 0.00182
-
at pH 8.4 and 37°C Homo sapiens quercitrin