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Literature summary extracted from

  • Kim, S.; Sieburth, D.
    Sphingosine kinase activates the mitochondrial unfolded protein response and is targeted to mitochondria by stress (2018), Cell Rep., 24, 2932-2945 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.91 mitochondrial membrane
-
 Caenorhabditis elegans 31966
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.91 ATP + sphingosine Caenorhabditis elegans
-
 ADP + sphingosine 1-phosphate
-
 ?
2.7.1.91 ATP + sphingosine Caenorhabditis elegans N2
-
 ADP + sphingosine 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Caenorhabditis elegans
-
-
-
2.7.1.91 Caenorhabditis elegans N2
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 intestine
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + sphingosine
-
 Caenorhabditis elegans ADP + sphingosine 1-phosphate
-
 ?
2.7.1.91 ATP + sphingosine
-
 Caenorhabditis elegans N2 ADP + sphingosine 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.91 sphingosine kinase-1
-
 Caenorhabditis elegans
2.7.1.91 SPHK-1 isoform Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
2.7.1.91 malfunction genetic deficiency of isoform sphk-1 in the intestine inhibits activation of the mitochondrial unfolded protein response Caenorhabditis elegans
2.7.1.91 physiological function isoform SPHK-1 activates the mitochondrial unfolded protein response Caenorhabditis elegans