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Literature summary extracted from

  • Hu, Z.; Qu, G.; Yu, X.; Jiang, H.; Teng, X.L.; Ding, L.; Hu, Q.; Guo, X.; Zhou, Y.; Wang, F.; Li, H.B.; Chen, L.; Jiang, J.; Su, B.; Liu, J.; Zou, Q.
    Acylglycerol kinase maintains metabolic state and immune responses of CD8+ T cells (2019), Cell Metab., 30, 290-302.e5 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.94 ATP + monoacylglycerol Mus musculus
-
 ADP + lysophosphatidic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.94 Mus musculus Q9ESW4
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.94 culture condition:CD8+ cell
-
 Mus musculus
-
2.7.1.94 T-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.94 ATP + monoacylglycerol
-
 Mus musculus ADP + lysophosphatidic acid
-
 ?
2.7.1.94 ATP + PTEN protein
-
 Mus musculus ADP + phosphorylated PTEN protein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.94 AGK
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.1.94 physiological function the enzyme is required for CD8+ T cell expansion, antitumor function and regulates CD8+ T cell glycolysis and activation of phosphatidylinositol-3-OH kinase-mammalian target of rapamycin. Enzyme-triggered PTEN inactivation promotes a CD8+ T cell metabolic switch Mus musculus