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Literature summary extracted from

  • Wang, X.; Xie, J.; Proud, C.G.
    Eukaryotic elongation factor 2 kinase (eEF2K) in cancer (2017), Cancers (Basel), 9, 162 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.20 Calmodulin
-
Homo sapiens
2.7.11.20 additional information the enzyme is activated under conditions of stress, such as energy depletion or nutrient deprivation, which can arise in poorly-vascularised tumours Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.20 A-484954
-
Homo sapiens
2.7.11.20 additional information the enzyme is not inhibited by staurosporine Homo sapiens
2.7.11.20 NH125
-
Homo sapiens
2.7.11.20 rottlerin
-
Homo sapiens
2.7.11.20 TX-1918
-
Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.20 Ca2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.20 ATP + [elongation factor 2] Homo sapiens
-
ADP + [elongation factor 2] phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.20 Homo sapiens O00418
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.20 phosphoprotein the enzyme autophosphorylates on Thr348. The enzyme is extensively regulated by phosphorylation. S6 kinase phosphorylates the enzyme on Ser366 and impairs its activation by Ca2+/calmodulin. Mammalian target of rapamycin complex 1 directly phosphorylates the enzyme on Ser78/Ser396 thereby negatively regulating the enzyme activity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.20 A-549 cell
-
Homo sapiens
-
2.7.11.20 breast cancer cell
-
Homo sapiens
-
2.7.11.20 breast epithelial cell
-
Homo sapiens
-
2.7.11.20 colonic cancer cell
-
Homo sapiens
-
2.7.11.20 colorectal cancer cell
-
Homo sapiens
-
2.7.11.20 glioma cell
-
Homo sapiens
-
2.7.11.20 HCT-116 cell
-
Homo sapiens
-
2.7.11.20 HT-29 cell
-
Homo sapiens
-
2.7.11.20 lung cancer cell
-
Homo sapiens
-
2.7.11.20 MCF-10A cell
-
Homo sapiens
-
2.7.11.20 MCF-7 cell
-
Homo sapiens
-
2.7.11.20 MDA-MB-468 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.20 ATP + [elongation factor 2]
-
Homo sapiens ADP + [elongation factor 2] phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.20 eEF2K
-
Homo sapiens
2.7.11.20 eukaryotic elongation factor 2 kinase
-
Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.11.20 Homo sapiens the enzyme is overexpressed in many tumours/cancers up

General Information

EC Number General Information Comment Organism
2.7.11.20 physiological function In many types of tumour cells, and likely in more advanced solid tumours, the enzyme helps protect cells against nutrient depletion and other stresses by slowing down protein synthesis (thereby conserving resources) and/or altering the translation rates of specific mRNAs and thus the levels of the corresponding proteins. The enzyme aids the growth of solid tumours in vivo and aids cell migration. The enzyme is required for the resistance of tumors to caloric restriction-induced cell death. The enzyme plays a role in protecting breast cancer cells against endoplasmic reticulum stress, apparently by activating autophagy Homo sapiens