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Literature summary extracted from

  • Fatima, M.; Ahmed, M.; Batool, F.; Riaz, A.; Ali, M.; Munch-Petersen, B.; Mutahir, Z.
    Recombinant deoxyribonucleoside kinase from Drosophila melanogaster can improve gemcitabine based combined gene/chemotherapy for targeting cancer cells (2019), Bosn. J. Basic Med. Sci., 19, 342-349 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.1.145 medicine the recombinant enzyme is used to sensitize human cancer cell lines to gemcitabine Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.145 the enzyme with a deletion of the last 20 amino acid residues is expressed in MCF-7-R cells Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.145 ATP + a 2'-deoxyribonucleoside Drosophila melanogaster
-
 ADP + a 2'-deoxyribonucleoside 5'-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.145 Drosophila melanogaster Q9XZT6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.145 ATP + a 2'-deoxyribonucleoside
-
 Drosophila melanogaster ADP + a 2'-deoxyribonucleoside 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.145 deoxyribonucleoside kinase
-
 Drosophila melanogaster
2.7.1.145 dNK
-
 Drosophila melanogaster