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Literature summary extracted from

  • Liu, S.; Hu, Z.; Zhang, Q.; Yang, X.; Critchley, A.; Duan, D.
    PI signal transduction and ubiquitination respond to dehydration stress in the red seaweed Gloiopeltis furcata under successive tidal cycles (2019), BMC Plant Biol., 19, 516 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.159 gene itpk, quantitative RT-PCR enzyme expression analysis Gloiopeltis furcata

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.159 ATP + 1D-myo-inositol 1,3,4-trisphosphate Gloiopeltis furcata
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 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
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 ?
2.7.1.159 ATP + 1D-myo-inositol 1,3,4-trisphosphate Gloiopeltis furcata
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 ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.159 Gloiopeltis furcata
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.159 additional information expression pattern of gene ITPK as a drought-related hub gene Gloiopeltis furcata
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.159 ATP + 1D-myo-inositol 1,3,4-trisphosphate
-
 Gloiopeltis furcata ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.159 ATP + 1D-myo-inositol 1,3,4-trisphosphate
-
 Gloiopeltis furcata ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate
-
 ?
2.7.1.159 ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate
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 Gloiopeltis furcata ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate
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 r
2.7.1.159 additional information ITPK can also interconvert Ins (3,4,5,6)P4 and Ins (1,3,4,5,6)P5 within a substrate cycle to regulate the concentration of Ins (3,4,5,6)P4 Gloiopeltis furcata ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.159 ITPK
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 Gloiopeltis furcata

Expression

EC Number Organism Comment Expression
2.7.1.159 Gloiopeltis furcata successive dehydration treatment induces the enzyme expression in red sea weed up

General Information

EC Number General Information Comment Organism
2.7.1.159 metabolism pathways enriched analysis indicates that the ubiquitin-mediated proteolysis pathway (UPP) and phosphatidylinositol (PI) signaling system are crucial for a successful transcriptional response in Gloiopeltis furcata to simulated natural tidal changes with twoconsecutive dehydration-rehydration cycles, overview. Genes encoding ubiquitin-protein ligase E3 (E3-1), SUMO-activating enzyme sub-unit 2 (SAE2), calmodulin (CaM), and inositol-1,3,4-trisphosphate 5/6-kinase (ITPK) are the hub genes which respond positively to two successive dehydration treatments. Network-based interactions with hub genes indicate that transcription factor (e.g. TFIID), RNA modification (e.g. DEAH) and osmotic adjustment (e.g. MIP, ABC1, Bam1) are related to these two pathways. The PI signal connected with Ca2+/CaM pathway responds to dehydration, and the role of CaM and ITPK in signal transduction Gloiopeltis furcata
2.7.1.159 physiological function enzyme ITPK is the key regulatory enzyme at the branch point for the synthesis of InsP4 isomers [e.g. Ins(1,3,4,5)P4, Ins(1,3,4,6)P4 and Ins(3,4,5,6)P4], inositol pentakisphosphate (InsP5) and inositol hexaphosphate (InsP6). Ins (3,4,5,6)P4 can act as second messenger and play important roles in signal transduction Gloiopeltis furcata