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Literature summary extracted from

  • Reidick, C.; Boutouja, F.; Platta, H.W.
    The class III phosphatidylinositol 3-kinase Vps34 in Saccharomyces cerevisiae (2017), Biol. Chem., 398, 677-685 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.137 endosome
-
 Saccharomyces cerevisiae 5768
-
2.7.1.137 multivesicular body
-
 Saccharomyces cerevisiae 5771
-
2.7.1.137 peroxisome
-
 Saccharomyces cerevisiae 5777
-
2.7.1.137 phagosome
-
 Saccharomyces cerevisiae
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.137 Mg2+ required Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol Saccharomyces cerevisiae
-
 ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Saccharomyces cerevisiae P22543
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Saccharomyces cerevisiae ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.137 More domain organization of phosphatidylinositol 3-kinase class III (PIK3C3) complex subunits in Saccharomyces cerevisiae, overview Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.7.1.137 class III phosphatidylinositol 3-kinase
-
 Saccharomyces cerevisiae
2.7.1.137 lipid kinase Vps34
-
 Saccharomyces cerevisiae
2.7.1.137 vacuolar protein sorting 34
-
 Saccharomyces cerevisiae
2.7.1.137 VPS34
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.137 ATP
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
2.7.1.137 malfunction the deletion of Vps34, Vps15 or Vps30 affects both autophagy and vacuolar protein sorting. The deletion of Vps34 or Vps15 results in a reduced mRNA production from G + C-rich coding sequences (CDS). Vps34 and Vps15 can enhance the efficiency of transcription elongation based on their physical proximity to nuclear pores and transcribed chromatin Saccharomyces cerevisiae
2.7.1.137 metabolism together with Vps34, Vps15 and Vps30 it forms the PIK3C3-Complex II, which is mainly found at endosomal membranes, modulation of PIK3C3 complex function through different subunit compositions, overview. The Vps15 kinase domain intercts with the Vps34 activation loop, which might regulate the activity of Vps34 Saccharomyces cerevisiae
2.7.1.137 physiological function PI3K-III (or PIK3C3) represents the most conserved PI3K class. It is the sole PI3K in yeast and plants. The catalytic subunit of the PI3K complex is Vps34, which exclusively utilizes PtdIns as substrate. It phosphorylates PtdIns at the 3-hydoxyl group of the inositol ring in order to generate PtdIns3P. Class III phosphatidylinositol 3-kinase Vps34 (vacuolar protein sorting 34) catalyzes for the formation of the signaling lipid phosphatidylinositol-3-phopsphate, which is a central factor in the regulation of autophagy, endocytic trafficking and vesicular transport. The Vps15 kinase domain interacts with the Vps34 activation loop, which might regulate the activity of Vps34. Regulation of Vps34 function by G-protein signaling. Vps34 and Vps15 act as suppressors of Gpa1 (Galpha)-mediated transcriptional responses involved in pheromone signaling. Direct link between trimeric G-proteins and Vps34p function in yeast Saccharomyces cerevisiae