Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Mezzar, S.; De Schryver, E.; Asselberghs, S.; Meyhi, E.; Morvay, P.L.; Baes, M.; Van Veldhoven, P.P.
    Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase (2017), Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1862, 972-990 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.2.63 peroxisome
-
Mus musculus 5777
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.1.2.63 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.63 2-hydroxyphytanoyl-CoA Mus musculus
-
pristanal + formyl-CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.63 Mus musculus Q9QXE0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.2.63 brain
-
Mus musculus
-
4.1.2.63 hepatocyte
-
Mus musculus
-
4.1.2.63 liver
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.63 2-hydroxyoctadecanoyl-CoA
-
Mus musculus heptadecanal + formyl-CoA
-
?
4.1.2.63 2-hydroxyphytanoyl-CoA
-
Mus musculus pristanal + formyl-CoA
-
?

Subunits

EC Number Subunits Comment Organism
4.1.2.63 homotetramer 4 * 60000, calculated from amino acid sequence Mus musculus

Synonyms

EC Number Synonyms Comment Organism
4.1.2.63 2-hydroxyacyl-CoA lyase
-
Mus musculus
4.1.2.63 HACL1
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.2.63 thiamine diphosphate
-
Mus musculus

General Information

EC Number General Information Comment Organism
4.1.2.63 malfunction enzyme deficiency is not associated with a severe phenotype, but in combination with phytanic acid intake it might present with phytanic acid elevation and resemble a Refsum like disorder Mus musculus