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Literature summary extracted from
- Generation of lysophosphatidylinositol by DDHD domain containing 1 (DDHD1) Possible involvement of phospholipase D/phosphatidic acid in the activation of DDHD1 (2010), Biochim. Biophys. Acta, 1801, 711-720 .
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.118 | ionomycin | - |
Homo sapiens |  |
| 3.1.1.118 | lysophosphatidic acid | weak activation | Homo sapiens | |
| 3.1.1.118 | lysophosphatidylinositol | weak activation | Homo sapiens | |
| 3.1.1.118 | additional information | not activated by phosphatidylethanolamine, phosphatidylcholine and free fatty acid | Homo sapiens | |
| 3.1.1.118 | phosphatidic acid | - |
Homo sapiens | |
| 3.1.1.118 | phosphatidylserine | - |
Homo sapiens | |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.1.118 | expressed in HEK-293 cells | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.1.118 | n-butanol | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.1.118 | membrane | - |
Homo sapiens | 16020 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.1.118 | Homo sapiens | Q8NEL9 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.1.118 | anti-FLAG-M2 agarose column chromatography | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.1.118 | 1-stearoyl-2-arachidonoyl-phosphatidylinositol + H2O | - |
Homo sapiens | 2-arachidonoyl-lysophosphatidylinositol + stearate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.1.118 | ? | x * 120000, FLAG-tagged enzyme, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.1.118 | DDHD domain-containing protein 1 | - |
Homo sapiens |
| 3.1.1.118 | DDHD1 | - |
Homo sapiens |
| 3.1.1.118 | PA-PLA1 | - |
Homo sapiens |
| 3.1.1.118 | phosphatidic acid-preferring phospholipase A1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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