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Literature summary extracted from

  • Merida, I.; Arranz-Nicolas, J.; Rodriguez-Rodriguez, C.; Avila-Flores, A.
    Diacylglycerol kinase control of protein kinase C (2019), Biochem. J., 476, 1205-1219 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.107 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol Homo sapiens
-
 ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Homo sapiens Q13574
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.107 phosphoprotein isoform DGKzeta is phosphorylated by protein kinase Calpha Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 immune system
-
 Homo sapiens
-
2.7.1.107 nervous system
-
 Homo sapiens
-
2.7.1.107 T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacyl-sn-glycerol
-
 Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.7.1.107 additional information isoform DGKzeta physically and functionally interacts with protein kinase Calpha. Diacylglycerol kinase control of protein kinase C facilitates cell-cell communication Homo sapiens ?
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 DGKzeta isoform Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.107 physiological function isoform DGKzeta modulates protein kinase C-dependent regulation of synapse plasticity. Isoform DGKzeta interaction with post-synaptic density 95/Discs-large/zona occludens-1-containing scaffolds restricts spatial activation of protein kinase Calpha. Isoform DGKzeta is a negative regulator of T-cell functions and a modulator of innate immunity Homo sapiens