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Literature summary extracted from

  • Bais, V.S.; Aggarwal, P.; Bharadwaj, P.; Prakash, B.
    Classification, characterization and structural analysis of sugar nucleotidylyltransferase family of enzymes (2020), Biochem. Biophys. Res. Commun., 525, 780-785 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.23 K421A the activity of the mutant is very low (less than 5%) in comparison to the wild type enzyme Candida albicans
2.7.7.23 N239A the activity of the mutant is very low (less than 10%) in comparison to the wild type enzyme Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.23 Mg2+ strictly required. One magnesium ion catalyzes the sugar-nucleotidyl transfer reaction. 5 mM used in assay conditions Candida albicans
2.7.7.23 Mg2+ strictly required. Two magnesium ions catalyze the sugar-nucleotidyl transfer reaction. 5 mM used in assay conditions Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate Mycobacterium tuberculosis
-
 diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate Candida albicans
-
 diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate Mycobacterium tuberculosis H37Rv
-
 diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.23 Candida albicans O74933
-
-
2.7.7.23 Mycobacterium tuberculosis P9WMN3
-
-
2.7.7.23 Mycobacterium tuberculosis H37Rv P9WMN3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 Mycobacterium tuberculosis diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 Candida albicans diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?
2.7.7.23 UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 Mycobacterium tuberculosis H37Rv diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.23 GlmU
-
 Mycobacterium tuberculosis
2.7.7.23 N-acetylglucosamine-1-phosphate uridyltransferase
-
 Mycobacterium tuberculosis
2.7.7.23 N-acetylglucosamine-1-phosphate uridyltransferase
-
 Candida albicans
2.7.7.23 UAP1
-
 Candida albicans