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Literature summary extracted from

  • Oi, A.; Katayama, S.; Hatano, N.; Sugiyama, Y.; Kameshita, I.; Sueyoshi, N.
    Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) (2017), Biochem. Biophys. Res. Commun., 482, 239-245 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.22 S308A the mutant enzyme is primarily localized to the nucleus Mus musculus
2.7.11.22 S308D the mutation mimicking the phosphorylated serine residue by aspartate substitution (S308D) changes CDKL5 localization to the cytosol Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.22 cytosol
-
 Mus musculus 5829
-
2.7.11.22 nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.22 ATP + 1-(beta-D-ribofuranosyl)-nicotinamide Mus musculus
-
 ADP + beta-nicotinamide D-ribonucleotide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.22 Mus musculus Q3UTQ8
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.22 central nervous system
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.22 ATP + 1-(beta-D-ribofuranosyl)-nicotinamide
-
 Mus musculus ADP + beta-nicotinamide D-ribonucleotide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.22 CDKL5
-
 Mus musculus
2.7.11.22 cyclin-dependent kinase-like 5
-
 Mus musculus
2.7.11.22 STK9
-
 Mus musculus