EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.91 | isoform SphK1 is expressed in Saccharomyces cerevisiae strain CGY32 | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.91 | (3S)-1-([4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl]phenyl]methyl)pyrrolidin-3-ol | - |
Homo sapiens | |
2.7.1.91 | (3S)-N-[(1S)-1-[4-[5-(2-cyclohexylethyl)-1,2,4-oxadiazol-3-yl]phenyl]propyl]-3-hydroxy-L-prolinamide | - |
Homo sapiens | |
2.7.1.91 | 1-[[4-(4-tert-butylphenoxy)-3-fluorophenyl]methyl]pyrrolidin-3-ol | - |
Homo sapiens | |
2.7.1.91 | PF-543 | potent, selective, sphingosine-competitive isoform SphK1 inhibitor | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.91 | 0.017 | - |
ATP | isoform SphK1, at pH 7.4 and 23°C | Homo sapiens | |
2.7.1.91 | 0.084 | - |
ATP | isoform SphK2, at pH 7.4 and 23°C | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.91 | Mg2+ | required for activity | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.91 | ATP + sphingosine | Homo sapiens | - |
ADP + sphingosine 1-phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.91 | Homo sapiens | Q9NRA0 | - |
- |
2.7.1.91 | Homo sapiens | Q9NYA1 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.91 | ATP + 7-nitro-2-1,3-benzoxadiazol-4-yl-labeled sphingosine | - |
Homo sapiens | ADP + 7-nitro-2-1,3-benzoxadiazol-4-yl-labeled sphingosine 1-phosphate | - |
? | |
2.7.1.91 | ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
? | |
2.7.1.91 | ATP + sphingosine-fluorescin | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.91 | sphingosine kinase 1 | - |
Homo sapiens |
2.7.1.91 | sphingosine kinase 2 | - |
Homo sapiens |
2.7.1.91 | SPHK1 | isoform | Homo sapiens |
2.7.1.91 | SPHK2 | isoform | Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.91 | 0.53 | - |
ATP | isoform SphK2, at pH 7.4 and 23°C | Homo sapiens | |
2.7.1.91 | 7 | - |
ATP | isoform SphK1, at pH 7.4 and 23°C | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.91 | 0.0000043 | - |
PF-543 | isoform SphK1, at pH 7.4 and 23°C | Homo sapiens |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.91 | 6.3 | - |
ATP | isoform SphK2, at pH 7.4 and 23°C | Homo sapiens | |
2.7.1.91 | 410 | - |
ATP | isoform SphK1, at pH 7.4 and 23°C | Homo sapiens |