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Literature summary extracted from

  • Koesoema, A.A.; Sugiyama, Y.; Sriwong, K.T.; Xu, Z.; Verina, S.; Standley, D.M.; Senda, M.; Senda, T.; Matsuda, T.
    Reversible control of enantioselectivity by the length of ketone substituent in biocatalytic reduction (2019), Appl. Microbiol. Biotechnol., 103, 9529-9541 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.B3 expressed in Escherichia coli Rosetta(DE3) cells Geotrichum candidum

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.B3 W288A (R)-selective mutant Geotrichum candidum
1.1.1.B3 W288I (R)-selective mutant Geotrichum candidum
1.1.1.B3 W288L the enantiopreference oft he mutant is intermediate between wild type (S)-selectivity and (R)-selectivity Geotrichum candidum
1.1.1.B3 W288M the enantiopreference of the mutant enzyme is similar to wild type ((S)-selectivity) Geotrichum candidum
1.1.1.B3 W288V (R)-selective mutant Geotrichum candidum

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B3 Geotrichum candidum M5A8V4
-
-
1.1.1.B3 Geotrichum candidum NBRC 4597 M5A8V4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B3 1-phenylbutan-1-one + NADH + H+
-
 Geotrichum candidum 1-phenylbutan-1-ol + NAD+
-
 ?
1.1.1.B3 1-phenylbutan-1-one + NADH + H+
-
 Geotrichum candidum NBRC 4597 1-phenylbutan-1-ol + NAD+
-
 ?
1.1.1.B3 1-phenylheptan-1-one + NADH + H+
-
 Geotrichum candidum 1-phenylheptan-1-ol + NAD+
-
 ?
1.1.1.B3 1-phenylheptan-1-one + NADH + H+
-
 Geotrichum candidum NBRC 4597 1-phenylheptan-1-ol + NAD+
-
 ?
1.1.1.B3 1-phenylhexan-1-one + NADH + H+
-
 Geotrichum candidum 1-phenylhexan-1-ol + NAD+
-
 ?
1.1.1.B3 1-phenylhexan-1-one + NADH + H+
-
 Geotrichum candidum NBRC 4597 1-phenylhexan-1-ol + NAD+
-
 ?
1.1.1.B3 1-phenylpentan-1-one + NADH + H+
-
 Geotrichum candidum 1-phenylpentan-1-ol + NAD+
-
 ?
1.1.1.B3 1-phenylpropan-1-one + NADH + H+
-
 Geotrichum candidum 1-phenylpropan-1-ol + NAD+
-
 ?
1.1.1.B3 3-heptanone + NADH + H+
-
 Geotrichum candidum 3-hexanol + NADH + H+
-
 ?
1.1.1.B3 acetophenone + NADH + H+
-
 Geotrichum candidum (1S)-1-phenylethanol + NAD+
-
 ?
1.1.1.B3 acetophenone + NADH + H+
-
 Geotrichum candidum NBRC 4597 (1S)-1-phenylethanol + NAD+
-
 ?
1.1.1.B3 heptan-2-one + NADH + H+
-
 Geotrichum candidum heptan-2-ol + NAD+
-
 ?
1.1.1.B3 heptan-3-one + NADH + H+
-
 Geotrichum candidum heptan-3-ol + NAD+
-
 ?
1.1.1.B3 heptan-4-one + NADH + H+
-
 Geotrichum candidum heptan-4-ol + NAD+
-
 ?
1.1.1.B3 hexan-2-one + NADH + H+
-
 Geotrichum candidum hexan-2-ol + NAD+
-
 ?
1.1.1.B3 hexan-3-one + NADH + H+
-
 Geotrichum candidum hexan-3-ol + NAD+
-
 ?
1.1.1.B3 nonan-2-one + NADH + H+
-
 Geotrichum candidum nonan-2-ol + NAD+
-
 ?
1.1.1.B3 nonan-3-one + NADH + H+
-
 Geotrichum candidum nonan-3-ol + NAD+
-
 ?
1.1.1.B3 nonan-4-one + NADH + H+
-
 Geotrichum candidum nonan-4-ol + NAD+
-
 ?
1.1.1.B3 nonan-5-one + NADH + H+
-
 Geotrichum candidum nonan-5-ol + NAD+
-
 ?
1.1.1.B3 octan-2-one + NADH + H+
-
 Geotrichum candidum octan-2-ol + NAD+
-
 ?
1.1.1.B3 octan-2-one + NADH + H+
-
 Geotrichum candidum NBRC 4597 octan-2-ol + NAD+
-
 ?
1.1.1.B3 octan-3-one + NADH + H+
-
 Geotrichum candidum octan-3-ol + NAD+
-
 ?
1.1.1.B3 octan-4-one + NADH + H+
-
 Geotrichum candidum octan-4-ol + NAD+
-
 ?
1.1.1.B3 pentan-2-one + NADH + H+
-
 Geotrichum candidum pentan-2-ol + NAD+
-
 ?
1.1.1.B3 pentan-3-one + NADH + H+
-
 Geotrichum candidum pentan-3-ol + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B3 acetophenone reductase
-
 Geotrichum candidum
1.1.1.B3 APRD
-
 Geotrichum candidum
1.1.1.B3 NAD+-dependent ADH
-
 Geotrichum candidum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B3 NAD+
-
 Geotrichum candidum