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Literature summary extracted from

  • Zhang, L.; Zhao, Z.; Wang, Y.; Li, N.; Cao, N.; Yang, L.
    Changes in expression of interferon-stimulated genes and ubiquitin activating enzyme E1-like in ovine thymus during early pregnancy (2020), Anim. Reprod., 17, e20190134 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.45 gene UBA1, real-time quantitative PCR enzyme expression analysis Ovis aries

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.45 Mg2+ required Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.45 ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine Ovis aries
-
 AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.45 Ovis aries A0A6P7D3I5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.45 thymus ovine thymuses are sampled on day 16 of the estrous cycle and on days 13, 16 and 25 of gestation, and UBE1L is detected by real-time quantitative PCR, Western blot and immunohistochemistry. The expression of UBE1L is declined during early pregnancy Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.45 ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine
-
 Ovis aries AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.45 UBA7
-
 Ovis aries
6.2.1.45 UBE1L
-
 Ovis aries
6.2.1.45 ubiquitin activating enzyme E1-like
-
 Ovis aries
6.2.1.45 ubiquitin-like modifier-activating enzyme 7 isoform X2 UniProt Ovis aries

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.45 ATP
-
 Ovis aries

Expression

EC Number Organism Comment Expression
6.2.1.45 Ovis aries expression of UBE1L declines during early pregnancy down

General Information

EC Number General Information Comment Organism
6.2.1.45 metabolism early pregnancy influences expression of STAT1, Mx1, IP-10 and UBE1L in maternal thymus, which may participate in regulation of maternal immune tolerance during early pregnancy in sheep Ovis aries
6.2.1.45 physiological function early pregnancy reduces expression of UBE1L in maternal thymus, which may participate in regulation of maternal immune tolerance during early pregnancy in sheep Ovis aries