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Literature summary extracted from

  • Scoumanne, A.; Molina-Ortiz, P.; Monteyne, D.; Perez-Morga, D.; Erneux, C.; Schurmans, S.
    Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice (2016), Adv. Biol. Regul., 62, 1-10 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.127 additional information generation of Itpkc-/- mice, a Itpkc knockout mouse model Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate Mus musculus
-
 ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Mus musculus Q7TS72
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 brain
-
 Mus musculus
-
2.7.1.127 bronchial epithelial cell
-
 Mus musculus
-
2.7.1.127 ependymocyte brain Mus musculus
-
2.7.1.127 kidney
-
 Mus musculus
-
2.7.1.127 large intestine
-
 Mus musculus
-
2.7.1.127 lung
-
 Mus musculus
-
2.7.1.127 additional information cells positive for ITPKC in the studied tissues express either a multicilium (tracheal and bronchial epithelia, brain ependymal cells), microvilli forming a brush border (small and large intestine, and kidney proximal tubule cells) or a flagellum (spermatozoa), suggesting a role for ITPKC either in the development or the function of these specialized cellular structures. Tissue expression and localization study, overview Mus musculus
-
2.7.1.127 renal proximal tubule cell
-
 Mus musculus
-
2.7.1.127 small intestine
-
 Mus musculus
-
2.7.1.127 spermatozoon
-
 Mus musculus
-
2.7.1.127 trachea
-
 Mus musculus
-
2.7.1.127 tracheal epithelium MTEC Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Mus musculus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.127 inositol 1,4,5-trisphosphate 3-kinase C
-
 Mus musculus
2.7.1.127 Ins(1,4,5)P3 3-kinase
-
 Mus musculus
2.7.1.127 Itpkc
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.1.127 evolution inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases family which phosphorylates inositol 1,4,5-trisphosphate into inositol 1,3,4,5-tetrakisphosphate Mus musculus
2.7.1.127 physiological function cells positive for ITPKC in the studied tissues express either a multicilium (tracheal and bronchial epithelia, brain ependymal cells), microvilli forming a brush border (small and large intestine, and kidney proximal tubule cells) or a flagellum (spermatozoa), suggesting a role for ITPKC either in the development or the function of these specialized cellular structures Mus musculus