Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yoshida, Y.; Fujigaki, H.; Kato, K.; Yamazaki, K.; Fujigaki, S.; Kunisawa, K.; Yamamoto, Y.; Mouri, A.; Oda, A.; Nabeshima, T.; Saito, K.
    Selective and competitive inhibition of kynurenine aminotransferase 2 by glycyrrhizic acid and its analogues (2019), Sci. Rep., 9, 10243 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.6.1.7 medicine isoform KAT2 is a therapeutic target for the management of schizophrenia Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.7 BFF-122
-
 Homo sapiens
2.6.1.7 BFF-816
-
 Homo sapiens
2.6.1.7 carbenoxolone highly selective and competitive inhibitor for isoform KAT2 Homo sapiens
2.6.1.7 glycyrrhetinic acid highly selective and competitive inhibitor for isoform KAT2 Homo sapiens
2.6.1.7 glycyrrhizic acid highly selective and competitive inhibitor for isoform KAT2 Homo sapiens
2.6.1.7 PF-04859989
-
 Homo sapiens
2.6.1.7 S-4-(ethylsulfonyl)benzoyl-L-alanine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.7 L-kynurenine + 2-oxoglutarate Homo sapiens
-
 kynurenic acid + L-glutamate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Homo sapiens Q8N5Z0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.7 L-kynurenine + 2-oxoglutarate
-
 Homo sapiens kynurenic acid + L-glutamate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.7 KAT2
-
 Homo sapiens
2.6.1.7 kynurenine aminotransferase 2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.7 pyridoxal 5'-phosphate
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.6.1.7 0.0039
-
 isoform KAT2, at pH 9.5 and 37°C Homo sapiens carbenoxolone
2.6.1.7 0.00451
-
 isoform KAT2, at pH 9.5 and 37°C Homo sapiens glycyrrhizic acid
2.6.1.7 0.00696
-
 isoform KAT2, at pH 9.5 and 37°C Homo sapiens glycyrrhetinic acid