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Literature summary extracted from

  • Montgomery, A.P.; Skropeta, D.; Yu, H.
    Transition state-based ST6Gal I inhibitors Mimicking the phosphodiester linkage with a triazole or carbamate through an enthalpy-entropy compensation (2017), Sci. Rep., 7, 14428 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.3.1 5'-deoxy-5'-([[(3-phenoxyphenyl)(phosphono)methoxy]carbonyl]amino)cytidine
-
 Homo sapiens
2.4.3.1 5'-deoxy-5'-[4-[(3-phenoxyphenyl)(phosphono)methyl]-1H-1,2,3-triazol-1-yl]cytidine
-
 Homo sapiens
2.4.3.1 5'-O-[hydroxy[(2R)-2-(3-phenoxyphenyl)-2-phosphonoethyl]phosphoryl]cytidine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.1 CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein Homo sapiens
-
 CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.1 Homo sapiens P15907
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.1 CMP-N-acetyl-beta-neuraminate + recombinant alpha-1-antitrypsin
-
 Homo sapiens CMP + ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
-
 Homo sapiens CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.1 beta-galactoside alpha-2,6-sialyltransferase I
-
 Homo sapiens
2.4.3.1 ST6Gal I
-
 Homo sapiens