Literature summary extracted from

Lo, B.K.M.; Archibong-Omon, A.; Ploutarchou, P.; Day, A.J.; Milner, C.M.; Williams, S.A.
Oocyte-specific ablation of N- and O-glycans alters cumulus cell signalling and extracellular matrix composition (2019), Reprod. Fertil. Dev., 31, 529-537 .

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.4.1.122	UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R	Mus musculus	-	UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.122	Mus musculus	Q9JJ06	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.4.1.122	oocyte	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.1.122	UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R	-	Mus musculus	UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.4.1.122	C1GALT1	-	Mus musculus
2.4.1.122	T-synthase	-	Mus musculus

General Information

EC Number	General Information	Comment	Organism
2.4.1.122	malfunction	the double mutant (DM) mouse generates oocytes lacking complex N- and O-glycans due to oocyte-specific deletion of core 1 beta1,3-galactosyltransferase (C1galt1) and N-acetylglucosaminyltransferase I (Mgat1) and has modified cumulus expansion. Oocyte-specific ablation of C1galt1 and Mgat1 may affect bone morphogenetic protein 15 synthesis or bioactivity, thereby reducing SMAD1/5/8 phosphorylation and hyaluronan production. The genotype of the DM mouse is oocyte-specific. Cumulus-oocyte complexes (COCs) from mice with oocyte-specific deletions of C1galt1 and Mgat1 have abnormal cumulus matrix that is resistant to hyaluronidase treatment	Mus musculus
2.4.1.122	physiological function	T-synthase is required for the generation of complex O-glycans. The O-glycosylation has been implicated in receptor signalling and cell-matrix interactions	Mus musculus

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Release 2023.1 (January 2023)