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Literature summary extracted from

  • Schlee, S.; Straub, K.; Schwab, T.; Kinateder, T.; Merkl, R.; Sterner, R.
    Prediction of quaternary structure by analysis of hot spot residues in protein-protein interfaces the case of anthranilate phosphoribosyltransferases (2019), Proteins, 87, 815-825 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.18 expressed in Escherichia coli M15 cells Staphylococcus aureus
2.4.2.18 expressed in Escherichia coli M15 cells Staphylococcus haemolyticus
2.4.2.18 expressed in Escherichia coli M15 cells Methanococcus voltae
2.4.2.18 expressed in Escherichia coli M15 cells Saccharolobus solfataricus
2.4.2.18 expressed in Escherichia coli M15 cells Pelodictyon luteolum
2.4.2.18 expressed in Escherichia coli M15 cells Petrotoga mobilis
2.4.2.18 expressed in Escherichia coli M15 cells Acetomicrobium mobile
2.4.2.18 expressed in Escherichia coli M15 cells Fructobacillus fructosus
2.4.2.18 expressed in Escherichia coli M15 cells Methanocella conradii
2.4.2.18 expressed in Escherichia coli M15 cells Coprococcus eutactus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.18 0.0021
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Petrotoga mobilis
2.4.2.18 0.0024
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Methanocella conradii
2.4.2.18 0.019
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Acetomicrobium mobile
2.4.2.18 0.02
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Methanococcus voltae
2.4.2.18 0.032
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Saccharolobus solfataricus
2.4.2.18 0.085
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Coprococcus eutactus
2.4.2.18 0.086
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Pelodictyon luteolum
2.4.2.18 0.116
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Staphylococcus haemolyticus
2.4.2.18 0.15
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Staphylococcus aureus
2.4.2.18 0.371
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Fructobacillus fructosus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.18 Mg2+ dependent on, 0.05 mM used in assay conditions Saccharolobus solfataricus
2.4.2.18 Mg2+ dependent on, 2 mM used in assay conditions Staphylococcus aureus
2.4.2.18 Mg2+ dependent on, 2 mM used in assay conditions Staphylococcus haemolyticus
2.4.2.18 Mg2+ dependent on, 2 mM used in assay conditions Methanococcus voltae
2.4.2.18 Mg2+ dependent on, 2 mM used in assay conditions Pelodictyon luteolum
2.4.2.18 Mg2+ dependent on, 2 mM used in assay conditions Petrotoga mobilis
2.4.2.18 Mg2+ dependent on, 2 mM used in assay conditions Acetomicrobium mobile
2.4.2.18 Mg2+ dependent on, 2 mM used in assay conditions Fructobacillus fructosus
2.4.2.18 Mg2+ dependent on, 2 mM used in assay conditions Methanocella conradii
2.4.2.18 Mg2+ dependent on, 2 mM used in assay conditions Coprococcus eutactus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.18 75000
-
 calculated from amino acid sequence Coprococcus eutactus
2.4.2.18 78200
-
 calculated from amino acid sequence Methanocella conradii
2.4.2.18 78700
-
 calculated from amino acid sequence Petrotoga mobilis
2.4.2.18 79200
-
 calculated from amino acid sequence Saccharolobus solfataricus
2.4.2.18 83700
-
 calculated from amino acid sequence Methanococcus voltae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Staphylococcus aureus
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Staphylococcus haemolyticus
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Methanococcus voltae
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Saccharolobus solfataricus
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Pelodictyon luteolum
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Petrotoga mobilis
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Acetomicrobium mobile
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Fructobacillus fructosus
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Methanocella conradii
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Coprococcus eutactus
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Saccharolobus solfataricus P2
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Staphylococcus aureus USA300
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Pelodictyon luteolum DSM270
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate Staphylococcus haemolyticus JCSC1435
-
 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.18 Acetomicrobium mobile
-
-
-
2.4.2.18 Coprococcus eutactus
-
-
-
2.4.2.18 Fructobacillus fructosus
-
-
-
2.4.2.18 Methanocella conradii
-
-
-
2.4.2.18 Methanococcus voltae
-
-
-
2.4.2.18 Pelodictyon luteolum
-
-
-
2.4.2.18 Pelodictyon luteolum DSM270
-
-
-
2.4.2.18 Petrotoga mobilis
-
-
-
2.4.2.18 Saccharolobus solfataricus P50384
-
-
2.4.2.18 Saccharolobus solfataricus P2 P50384
-
-
2.4.2.18 Staphylococcus aureus
-
-
-
2.4.2.18 Staphylococcus aureus USA300
-
-
-
2.4.2.18 Staphylococcus haemolyticus
-
-
-
2.4.2.18 Staphylococcus haemolyticus JCSC1435
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.18 Mono Q column chromatography Methanococcus voltae
2.4.2.18 Mono Q column chromatography Saccharolobus solfataricus
2.4.2.18 Mono Q column chromatography Petrotoga mobilis
2.4.2.18 Mono Q column chromatography Acetomicrobium mobile
2.4.2.18 Mono Q column chromatography Fructobacillus fructosus
2.4.2.18 Mono Q column chromatography Coprococcus eutactus
2.4.2.18 MonoQ column chromatography Staphylococcus aureus
2.4.2.18 MonoQ column chromatography Staphylococcus haemolyticus
2.4.2.18 MonoQ column chromatography Pelodictyon luteolum
2.4.2.18 MonoQ column chromatography Methanocella conradii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Staphylococcus aureus N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Staphylococcus haemolyticus N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Methanococcus voltae N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Saccharolobus solfataricus N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Pelodictyon luteolum N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Petrotoga mobilis N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Acetomicrobium mobile N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Fructobacillus fructosus N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Methanocella conradii N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Coprococcus eutactus N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Saccharolobus solfataricus P2 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Staphylococcus aureus USA300 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Pelodictyon luteolum DSM270 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?
2.4.2.18 anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Staphylococcus haemolyticus JCSC1435 N-(5-phospho-D-ribosyl)-anthranilate + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.18 homodimer 2 * 37500, calculated from amino acid sequence Coprococcus eutactus
2.4.2.18 homodimer 2 * 41900, calculated from amino acid sequence Methanococcus voltae
2.4.2.18 monomer 1 * 38500, calculated from amino acid sequence Staphylococcus aureus
2.4.2.18 monomer 1 * 39400, calculated from amino acid sequence Staphylococcus haemolyticus
2.4.2.18 monomer 1 * 39800, calculated from amino acid sequence Pelodictyon luteolum

Synonyms

EC Number Synonyms Comment Organism
2.4.2.18 AnPRT
-
 Staphylococcus aureus
2.4.2.18 AnPRT
-
 Staphylococcus haemolyticus
2.4.2.18 AnPRT
-
 Methanococcus voltae
2.4.2.18 AnPRT
-
 Saccharolobus solfataricus
2.4.2.18 AnPRT
-
 Pelodictyon luteolum
2.4.2.18 AnPRT
-
 Petrotoga mobilis
2.4.2.18 AnPRT
-
 Acetomicrobium mobile
2.4.2.18 AnPRT
-
 Fructobacillus fructosus
2.4.2.18 AnPRT
-
 Methanocella conradii
2.4.2.18 AnPRT
-
 Coprococcus eutactus
2.4.2.18 TrpD
-
 Staphylococcus aureus
2.4.2.18 TrpD
-
 Staphylococcus haemolyticus
2.4.2.18 TrpD
-
 Methanococcus voltae
2.4.2.18 TrpD
-
 Saccharolobus solfataricus
2.4.2.18 TrpD
-
 Pelodictyon luteolum
2.4.2.18 TrpD
-
 Petrotoga mobilis
2.4.2.18 TrpD
-
 Acetomicrobium mobile
2.4.2.18 TrpD
-
 Fructobacillus fructosus
2.4.2.18 TrpD
-
 Methanocella conradii
2.4.2.18 TrpD
-
 Coprococcus eutactus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.4.2.18 44.7
-
 melting temperature Staphylococcus aureus
2.4.2.18 44.8
-
 melting temperature Staphylococcus haemolyticus
2.4.2.18 49.8
-
 melting temperature Pelodictyon luteolum
2.4.2.18 55.3
-
 melting temperature Coprococcus eutactus
2.4.2.18 56.2
-
 melting temperature Petrotoga mobilis
2.4.2.18 62.1
-
 melting temperature Methanococcus voltae
2.4.2.18 68.3
-
 melting temperature Methanocella conradii
2.4.2.18 91.1
-
 melting temperature Saccharolobus solfataricus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.2.18 0.00016
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Acetomicrobium mobile
2.4.2.18 0.00067
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Methanococcus voltae
2.4.2.18 0.13
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Methanocella conradii
2.4.2.18 0.18
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Saccharolobus solfataricus
2.4.2.18 0.25
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Petrotoga mobilis
2.4.2.18 0.27
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Coprococcus eutactus
2.4.2.18 0.28
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Pelodictyon luteolum
2.4.2.18 0.42
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Staphylococcus haemolyticus
2.4.2.18 0.43
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Staphylococcus aureus
2.4.2.18 0.44
-
 5-phospho-alpha-D-ribose 1-diphosphate at pH 7.5 and 25°C Fructobacillus fructosus