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Literature summary extracted from

  • Lopez-Haber, C.; Levin-Konigsberg, R.; Zhu, Y.; Bi-Karchin, J.; Balla, T.; Grinstein, S.; Marks, M.S.; Mantegazza, A.R.
    Phosphatidylinositol-4-kinase IIalpha licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells (2020), Proc. Natl. Acad. Sci. USA, 117, 28251-28262 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.67 phagosome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Mus musculus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 bone marrow
-
 Mus musculus
-
2.7.1.67 dendritic cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.67 phosphatidylinositol-4-kinase IIalpha
-
 Mus musculus
2.7.1.67 PI4KIIalpha
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.1.67 malfunction enzyme knockdown of isoform PI4KIIalpha -but not PI4KIIbeta - impairs toll-interleukin 1 receptor domain-containing adaptor protein and toll-like receptor 4 localization to phagosomes, reduces proinflammatory cytokine secretion, abolishes phagosomal tubule formation, and impairs major histocompatibility complex II presentation Mus musculus
2.7.1.67 physiological function isoform PI4KIIalpha is an essential regulator of phagosomal toll-like receptor signaling in dendritic cells by ensuring optimal toll-interleukin 1 receptor domain-containing adaptor protein recruitment to phagosomes Mus musculus