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Literature summary extracted from

  • Marks, J.; Kannan, K.; Roncase, E.J.; Klepacki, D.; Kefi, A.; Orelle, C.; Vazquez-Laslop, N.; Mankin, A.S.
    Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center (2016), Proc. Natl. Acad. Sci. USA, 113, 12150-12155 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.12 chloramphenicol CHL, inhibits protein synthesis by targeting the peptidyl transferase center of the bacterial ribosome. Analysis of the binding site of CHL in the peptidyl transferase center of the 50S ribosomal subunit, overview. The identity of the penultimate residue of the nascent peptide is critical for the inhibitory activity, specificity and mechanism Escherichia coli
2.3.2.12 linezolid LZD, inhibits protein synthesis by targeting the peptidyl transferase center of the bacterial ribosome. Analysis of the binding site of LZD in the peptidyl transferase center of the 50S ribosomal subunit, overview. The identity of the penultimate residue of the nascent peptide is critical for the inhibitory activity, specificity and mechanism Escherichia coli
2.3.2.12 additional information reevaluation of the mechanism of inducible CHL resistance. CHL and LZD poorly inhibit peptide bond formation when glycine residues are involved. Induction of CHL resistance genes relies on the stimulatory effect of the penultimate residue of the nascent chain on drug action Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.12 ribosome
-
 Escherichia coli 5840
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2 Escherichia coli
-
 tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.12 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.12 peptidyl-tRNA1 + aminoacyl-tRNA2
-
 Escherichia coli tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.12 peptidyl transferase center
-
 Escherichia coli
2.3.2.12 PTC
-
 Escherichia coli